Abstract
ObjectivesEpilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors (CRFs), antiepileptic drugs (AEDs), and etiology.Material and MethodsA single‐center retrospective epilepsy cohort from the decade of 2004–2013 was assessed. Poisson regression models with robust variance were estimated to obtain CRF prevalence ratios (PR) according to AED prescription and etiology.ResultsAfter excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme‐inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1.77, p < .05), compared to valproic acid. No etiology was associated with higher prevalence of any CRF.ConclusionsPatients treated with EIAEDs, especially PHT, had higher prevalence of dyslipidemia.
Highlights
Epilepsy is one of the most prevalent chronic neurologic disorders (World Health Organization, 2015)
There is a lack of information about the prevalence of dyslipidemia related to the use of antiepileptic drugs (AEDs), which would facilitate appropriate management to reduce the risk of vascular diseases
Our study showed that dyslipidemia was the most frequent cardiovascular risk factors (CRFs) and its presence was associated with enzyme-inducer AEDs (EIAEDs) therapy
Summary
Epilepsy is one of the most prevalent chronic neurologic disorders (World Health Organization, 2015). There is a lack of information about the prevalence of dyslipidemia related to the use of AEDs, which would facilitate appropriate management to reduce the risk of vascular diseases. Another AED that has been related to vascular risk factors is valproic acid (VPA), which has been associated with metabolic syndrome (Kim & Lee, 2007). For these reasons, some authors have suggested starting new AEDs in newly diagnosed patients or changing EIAEDs if patients experience metabolism-related effects (Brodie et al, 2013). The specific aim of the study was to assess whether there was an association between prescribed AEDs, epilepsy etiology, and classic CRFs
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