Abstract
Despite the importance of C. difficile infection (CDI) as a cause of hospital-acquired diarrhea, few studies have investigated the prevalence of asymptomatic C. difficile colonization in a broad cross-section of the general hospital patient population over multiple years and seasons.
Highlights
Despite the importance of C. difficile infection (CDI) as a cause of hospital-acquired diarrhea, few studies have investigated the prevalence of asymptomatic C. difficile colonization in a broad cross-section of the general hospital patient population over multiple years and seasons
To estimate the prevalence of asymptomatic C. difficile colonization of tertiary hospitals in different Australian States during six time-periods 2012-2014 and to describe the diversity of PCR ribotypes isolated from asymptomatic patients
High variability of asymptomatic C. difficile colonization prevalence was observed across seasons
Summary
Despite the importance of C. difficile infection (CDI) as a cause of hospital-acquired diarrhea, few studies have investigated the prevalence of asymptomatic C. difficile colonization in a broad cross-section of the general hospital patient population over multiple years and seasons. Observed in Aug-Sep 2014 (5.84%; 95% CI 3.30-9.44). A seasonal pattern characterized by lower prevalence in late winter (OR 0.63; 95% CI 0.42–0.94) was identified. The majority of the isolates (77.55%) were toxigenic C. difficile strains, PCR 014 and 018 were the most frequent toxigenic strains isolated
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