Abstract
Background Aim Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. Material and Methods Methodology Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by 2 two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical index (PAI). Data included systemic health, technical quality of root fillings, total number of teeth, quality of restoration, and periapical status. Statistical evaluation of differences between groups included used chi-squared tests and Fisher’s exact tests. Results The prevalence of root canal-treated teeth was 10.11% in the MM group and 12.05% in the control group (p=0.90). The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p=0.05). AP in 1 or more teeth was found in 86 % and in 78% of the patients in the MM and the control groups, respectively. When analyzed by subject, there was no statistically significant difference in the prevalence of AP (p>0.72). Similarly there was also no statistically significant difference in the prevalence of PA (p=0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups. Conclusions The presence of AP and endodontic treatment was not significantly different in individuals with MM compared with control subjects. Future studies are needed to elucidate and confirm the association between MM and AP. Key words:Apical periodontitis, multiple myeloma, endodontics, root canal treatment, systemic disease.
Highlights
Apical periodontitis (AP) is the inflammation and destruction of the periapical tissues as a consequence of a pulpal necrosis
When dental and medical scientific communities have analyzed the relation between apical periodontitis (AP) and systemic health [6], the results suggest an association between PA and diabetes mellitus [7], coronary heart disease [8], tobacco smoking [9] and other diseases like respiratory diseases [10] or osteoporosis in post menopause women [11]
The purpose of this study was to evaluate the presence of apical periodontitis and endodontic treatments in patients with myeloma multiple in comparison with subjects without myeloma multiple
Summary
Apical periodontitis (AP) is the inflammation and destruction of the periapical tissues as a consequence of a pulpal necrosis. AP is a fairly frequent condition that increases with age It occurs in 34 to 61% of people and 2.8 to 4.2% of teeth in Europe [3]. The purpose of this study was to evaluate the presence of apical periodontitis and endodontic treatments in patients with myeloma multiple in comparison with subjects without myeloma multiple. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p=0.05). There was no statistically significant difference in the prevalence of PA (p=0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups. Future studies are needed to elucidate and confirm the association between MM and AP
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