Abstract
OBJECTIVE: To define whether antiphospholipid antibodies (APA) are associated with unexplained infertility (UI) as they are with other reproductive problems DESIGN: Case-control study MATERIALS AND METHODS: 715 participants including 510 with unexplained infertility and 205 fertile control women had blood drawn for determination of 21 APA including IgG, IgM, and IgA anticardiolipin (CL), antiphosphatidyl ethanolamine (PE), antiphosphatidyl inositol (PI), antiphospatidic acid (PA), anti phosphatidyl glycerol (PG), antiphosphatidyl choline (PC), and antiphosphatidyl serine (PS) by ELISA . RESULTS: The frequencies of APA among women with UI compared with fertile controls are listed in Table. More than 1 positive APA was noted in 12% of women with UI compared with 1.5% of control women (P=0.002).Tabled 1Table. The percent positives for all 21 different APA among women with UI and with fertile controls.Antiphospholipid Ig GUI % (n=510)Controls % (n=205)P-valueCL5.50.50.004PE2.72.4NSPI4.31.9NSPA11.24.90.01PG5.91.90.04PC3.71.5NSPS1.44.9NSAntiphospholipid Ig MCL1.61.9NSPE0.21.9NSPI1.80.9NSPA2.40.9NSPG1.80.5NSPC7.80.90.0008PS1.90.5NSAntiphospholipid Ig ACL0.20.9NSPE1.21.5NSPI0.90.9NSPA00.9NSPG0.60.9NSPC0.80.5NSPS00.5NS Open table in a new tab CONCLUSIONS: APA appears to be significantly associated with UI.
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