Abstract
Sera and cerebrospinal fluids (CSF) from 10 patients with subacute sclerosing panencephalitis (SSPE) were tested for antibodies to the BK virus, a new tentative member of the papovavirus group, in an effort to determine any relationships between BK virus and SSPE and the papova-like virus seen in glial cells of SSPE patients. Serum specimens from a group of 50 multiple sclerosis (MS) patients and from corresponding control groups were also included in the tests. All the CSF samples were antibody negative. The prevalence of antibodies in the SSPE and the MS groups, 70% and 60% respectively, and the distributions of individual titers were similar to those in the corresponding control groups. These results suggest that BK virus probably has no connection with SSPE. Further studies of the etiological role of the BK virus in human diseases and the role of the papova-like virus seen in SSPE patients' brains are needed.
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