Prevalence of Anti-SARS-CoV-2 Antibody in Hospital Staff in Double-Center Setting: A Preliminary Report of a Cohort Study From Iran

Abstract

Background: The outbreak of COVID-19 in China in late 2019 was an unprecedented catastrophe that also involved many other countries, including Iran. Concerning the danger of disease contagion, it is necessary to detect asymptomatic or mild cases, especially in hospital staff who are highly exposed to the disease. Objectives: In this serosurvey study, we aimed to estimate IgG seroprevalence among hospital staff in two public hospitals to determine local transmission and infection risk factors, as well as protective immunity among high-risk populations. Methods: Screening was offered to the hospital staff of two public hospitals in Shiraz, Iran. Screening involved the measurement of IgG antibodies against SARS-CoV-2. Besides, a checklist that consisted of questions about sociodemographic, occupational, and epidemiological characteristics was completed by the participants. Results: Among 494 participants in this study, 29 (5.8%) had anti-SARS-CoV-2 IgG in their blood. Besides, 320 (64.8%) had at least one of the clinical symptoms within six months before this survey. Among participants with positive PCR, nine (21.4%) had anti-SARS-CoV-2 IgG, while this figure was seven (33.3%) for individuals with positive CT scans. Non-proper disposal of used protective equipment or infectious wastes (OR = 26.5), rotational daily work shifts (OR = 7.5), being anxious about getting COVID-19 (OR = 3.8), and age (OR = 1.06) were the significant determinants of having anti-SARS-CoV-2 IgG in the hospital staff. Conclusions: It is essential to continue training and giving technical consultations about COVID-19, especially the proper disposal of used protective equipment or infectious wastes in rotational daily shift workers.