Abstract
Recent studies are lacking in assessing presence of both the anti-gastric parietal cell (GPC) antibody and concurrent vitamin B12 deficiency in Rheumatoid Arthritis (RA) patients in the era of more aggressive disease modifying therapy. We recruited patients to one of three arms:
Highlights
Rheumatoid Arthritis (RA) is a chronic systemic inflammatory and immune-mediated disease with both articular and extra-articular manifestations
The purpose of the autoimmune thyroid disease (AITD) arm was that it would represent a cohort of subjects with an autoimmune disease which can be associated with other organ specific or systemic autoimmune illnesses and subjects with AITD would not typically be treated with disease modifying anti-rheumatic drugs (DMARDs) or biologic response modifiers (BRMs) for this condition
Most (97.8%) subjects in the RA group were treated at some time with DMARDs and/ or BRMs
Summary
Rheumatoid Arthritis (RA) is a chronic systemic inflammatory and immune-mediated disease with both articular and extra-articular manifestations. It manifests with synovial inflammation, autoantibody production, cartilage and bone destruction, and systemic features such as accelerated cardiovascular disease and osteoporosis. Two well described autoantibodies associated with RA are the rheumatoid factor (RF) and anti-citrillunated protein antibody (detected using an anti-cyclic citrullinated peptide (anti-CCP) IgG assay). These autoantibodies can be often be detected in patients before the development of arthritis. Production can be stimulated by infection (response of RF which has a high-affinity against the Fc portion of the immunoglobin) or by various cytokines (interleukin-6 propagates leukocyte activation and autoantibody formation) [1]
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