Abstract
Background Odor identification is a complex process involving different neuronal mechanisms. It is important from different aspects of quality of life. Postviral neuritis is one of the leading causes of hyposmia. Attention to it has increased in the last year due to the coronavirus disease 2019 pandemic. Systemic steroids are presumed to benefit such cases through its anti‑inflammatory mechanism of action. Cinnarizine, being a multimodal mechanism of action drug with a potent cerebral vasodilator effect, is assumed to have a great potential to be used as adjuvant treatment to systemic steroids. Objective The aim of the study is to assess if there is any role of Cinnarizine as an adjuvant treatment to steroids in cases of postviral hyposmia. Patients and methods This is a single‑blinded, randomized, controlled trial including 82 patients with postviral hyposmia. Patients were distributed equally into two groups according to the given therapy with group I receiving 25 mg oral prednisolone per day for 2 weeks along with budesonide nasal spray/64 µg per puff in a dose of two puffs for each nostril twice daily for 1 month, in addition to our drug of study Cinnarizine 25 mg given postoperative TDS for 1 month. Group II received the same but without Cinnarizine. Both groups were compared regarding the number and percentage of patients having their smell identification test score improved either partially or fully back to normal. Results Cinnarizine intake as an adjuvant treatment to steroids had a significant effect on improving the smell identification test scores in patients with postviral hyposmia (PË‚0.05). However, among the improved patients in both groups, there was a nonsignificant difference between the two groups regarding the degree of recovery whether complete or partial (P=0.78). Conclusion Cinnarizine has a beneficial effect as an adjuvant treatment to steroids in cases of postviral hyposmia. Keywords: anosmia, hyposmia, olfaction Cinnarizine, olfactory, Stugeron
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