Abstract
Background: Allergic bronchopulmonary aspergillosis (ABPA) is a complex pulmonary disease caused by immunologic inflammatory responses to the presence of Aspergillus mycelia in the airways. It occurs in some patients with primary airway disease such as cystic fibrosis, bronchiectasis and asthma. Objective: The aim of this study was to determine the frequency of skin test reactivity to Aspergillus fumigatus and the prevalence of ABPA in patients with asthma. Methods: Fifty nine adult patients with uncontrolled asthma were included in this study. Skin prick tests to Aspergillus fumigatus and Candida albicans , peripheral eosinophil count, total serum IgE, specific IgE and IgG against Aspergillus fumigatus as well as bronchodilator reversibility tests and radiologic studies were done for each patient. Results: Ten (17%) patients had positive skin tests to Aspergillus but only 2 of these patients met the diagnostic criteria for ABPA. Conclusion: In addition to skin tests for reactivity to Aspergillus fumigatus , additional serological tests to determine specific antibodies against Aspergillus and imaging studies should be done to diagnose ABPA in patients with uncontrolled asthma.
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