Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis

Djuraev Jamolbek Abdukhakhorovich*

doi:10.35940/ijadst.b1004.081221

Abstract

Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.

Highlights

Chronic polyposis rhinosinusitis (CPRS) is classified as an urgent problem of otorhinolaryngology due to the high prevalence of the disease and its medico-social significance [1,2,3].The last decades have been characterized by an increasing scale of study of the prevalence of CPRS, but the results of the studies differ in a variety of methods, and the data obtained are not very comparable
CPRS is an important medical and social problem due to its prevalence, combination with other diseases, prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients
The actual distribution of the rs2243250 polymorphism genotypes corresponded to those expected at Hardy-Weinberg equilibrium (RHW)

Summary

Introduction

Chronic polyposis rhinosinusitis (CPRS) is classified as an urgent problem of otorhinolaryngology due to the high prevalence of the disease and its medico-social significance [1,2,3].The last decades have been characterized by an increasing scale of study of the prevalence of CPRS, but the results of the studies differ in a variety of methods, and the data obtained are not very comparable. Chronic polyposis rhinosinusitis (CPRS) is classified as an urgent problem of otorhinolaryngology due to the high prevalence of the disease and its medico-social significance [1,2,3]. Summarizing the data of world statistics, we can conclude that CPRS affects 2-4% of the population, while in 40% of patients CPRS is combined with bronchial asthma. CPRS is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Revised Manuscript received on July 24, 2021 Manuscript published on August, 10 2021. Revised Manuscript received on July 24, 2021 Manuscript published on August, 10 2021. * Correspondence Author

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Results

Conclusion