PREVALENCE OF ACTINIC CHEILITIS AND LIP SQUAMOUS CELL CARCINOMA AMONG LIP LESIONS

Abstract

Objectives To investigate the prevalence of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) among lip lesions in an oral pathology service and compare the results with literature data. Study Design A retrospective review of histopathologic and biopsy files of patients with lip lesions from an oral pathology service was conducted. Data regarding clinical characteristics and diagnosis were retrieved. A literature review (LR) of similar studies was performed in PubMed, Wiley Online Library, Science Direct, and Google Scholar databases. Results Among 809 files of lip manifestations, there were 81 cases of AC (10.0%) and 46 cases of LSCC (5.7%). Both AC and LSCC mostly affected males (80.2% and 78.3%, respectively). From the LR, 4 articles were included. Overall, 2201 cases of lip manifestations were enrolled, of which 166 were from AC (7.5%) and 122 were from LSCC (5.5%). There was a male predominance in AC (75.3%) and LSCC (64.8%). Pooled data from the main study and LR showed that the prevalence of AC was 12.5% and the prevalence of LSCC was 6.9%. Conclusions The elevated prevalence of AC, a potentially malignant disorder, reinforces the importance of early diagnosis of lip lesions. To investigate the prevalence of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) among lip lesions in an oral pathology service and compare the results with literature data. A retrospective review of histopathologic and biopsy files of patients with lip lesions from an oral pathology service was conducted. Data regarding clinical characteristics and diagnosis were retrieved. A literature review (LR) of similar studies was performed in PubMed, Wiley Online Library, Science Direct, and Google Scholar databases. Among 809 files of lip manifestations, there were 81 cases of AC (10.0%) and 46 cases of LSCC (5.7%). Both AC and LSCC mostly affected males (80.2% and 78.3%, respectively). From the LR, 4 articles were included. Overall, 2201 cases of lip manifestations were enrolled, of which 166 were from AC (7.5%) and 122 were from LSCC (5.5%). There was a male predominance in AC (75.3%) and LSCC (64.8%). Pooled data from the main study and LR showed that the prevalence of AC was 12.5% and the prevalence of LSCC was 6.9%. The elevated prevalence of AC, a potentially malignant disorder, reinforces the importance of early diagnosis of lip lesions.