Abstract
What is already known about this topic?The association of diabetes mellitus (DM) with both increased risk of tuberculosis (TB) and unfavorable treatment outcomes has been identified by many studies (1). However, epidemic data for TB cases in DM patients is absent in China. What is added by this report?This current population-based prospective cohort study, conducted in ten counties located in eastern, central, and western China during 2013–2015, revealed a high prevalence and incidence of TB in known DM patients. Most TB cases were captured by active case-finding and a much higher presence of being asymptomatic among TB/DM patients was obtained.What are the implications for public health practice?Active case-finding should be carried out in DM patients and populations at high risk for developing TB. A TB symptom screening-based case-finding strategy is not enough; chest radiography check should be done once a year for these patients.
Highlights
The evidence for positive association of diabetes mellitus (DM) and tuberculosis (TB) has been found by many studies regardless of study design and population [1], and the risk for developing TB increased among DM patients
The study observed a higher prevalence of bacteriologically-confirmed TB in known DM patients than that for the general population based on data obtained from the Fifth National Tuberculosis Prevalence Survey
Male DM patients with lower body mass index (BMI) had higher TB prevalence and incidence rates; these findings were like those identified in the general population and could be found in retrospective cohort study conducted in Shanghai [6]
Summary
Prevalence, Incidence, and Characteristics of Tuberculosis Among Known Diabetes Patients — A Prospective Cohort Study in 10 Sites, 2013–2015. This current population-based prospective cohort study, conducted in ten counties located in eastern, central, and western China during 2013–2015, revealed a high prevalence and incidence of TB in known DM patients. Active case-finding should be carried out in DM patients and populations at high risk for developing TB. The evidence for positive association of diabetes mellitus (DM) and tuberculosis (TB) has been found by many studies regardless of study design and population [1], and the risk for developing TB increased among DM patients. A population-based multicenter prospective cohort study for TB incidence in 10 study sites from 10 provincial-level administrative divisions in China was conducted during 2013–2015. We made a doorto-door investigation to identify DM patients missed by the NPHSP
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