Abstract
Background Tuberculosis (TB) is a serious public health threat in low- and middle-income countries like Nepal. Chronic kidney disease (CKD) patients are at higher risk of developing new infection as well as reactivation of TB. We aimed to determine the prevalence, clinical presentations, and outcome of TB in patients with CKD in Nepal. Methods A hospital-based cross-sectional study was performed at Tribhuvan University Teaching Hospital (TUTH), a tertiary level referral centre in Kathmandu, Nepal. We included patients older than 16 years with the diagnosis of CKD stage 3, 4, 5, and 5D (CKD 5 on maintenance dialysis); renal transplant recipients and patients living with HIV/AIDS were excluded. Tuberculosis was diagnosed based on clinical, radiological, and laboratory findings. Prior written informed consent was obtained. Approval was obtained from the Institutional Review Board of the Institute of Medicine. Data entry and statistical analysis were performed using SPSS v21. Results A total of 401 patients with CKD were included in the study (mean age, 50.92 ± 17.98 years; 64.8% male). The prevalence of TB in CKD patients was found to be 13.7% (55), out of which 49 were newly diagnosed cases. The most common clinical presentations of TB in CKD were anorexia (85.7%), fever (83.7%), weight loss (51%), and cough (49%). Thirty-eight patients (69.1%) had extrapulmonary TB (EPTB), 12 (21.8%) had pulmonary TB, 3 (5.5%) had disseminated TB, and 2 (3.6%) had miliary TB. Only 4.1% of cases were sputum smear positive. Pleural effusion (34.2%) was the most common EPTB. At 2 months of starting antitubercular therapy, 29 patients out of the 49 newly diagnosed cases of TB (59.2%) had responded to therapy. Mortality at 2 months was 28.6% (14 died amongst 49 patients). Four out of 49 patients (8.2%) did not improve, and 2 (4%) patients were lost to follow-up. Conclusion Prevalence and mortality of TB were higher in patients with CKD. Special attention must be given to these people for timely diagnosis and treatment as the presentation is different and diagnosis can be missed.
Highlights
Tuberculosis (TB) is a serious public health threat in low- and middle-income countries like Nepal
A report from Australia showed that the incidence of TB in Chronic kidney disease (CKD) patients under Maintenance hemodialysis (MHD) was significantly higher in patients born in the highest TB incidence countries (698 per 100,000 per year) compared to those born in low TB incidence countries (18 per 100,000 per year) [22]. is is because active TB results from reactivation of latent tuberculosis infection (LTBI) acquired before dialysis initiation rather than from recent exposure and infection
We discovered varied clinical presentation of tuberculosis: decreased appetite (85.7%), fever (83.7%), weight loss (51%), cough (49%), dyspnea (46.9%), chest pain (20.4%), and hemoptysis (4.1%) (Table 3). ese features may be attributed to inadequate dialysis, volume overload, uremic symptoms, or complication of hemodialysis in patients with CKD, and this may lead to delay in the diagnosis and treatment of TB, leading to worse prognosis
Summary
Tuberculosis (TB) is a serious public health threat in low- and middle-income countries like Nepal. Chronic kidney disease (CKD) patients are at higher risk of developing new infection as well as reactivation of TB. We aimed to determine the prevalence, clinical presentations, and outcome of TB in patients with CKD in Nepal. A total of 401 patients with CKD were included in the study (mean age, 50.92 ± 17.98 years; 64.8% male). E prevalence of TB in CKD patients was found to be 13.7% (55), out of which 49 were newly diagnosed cases. Chronic kidney disease (CKD) is a global health problem with estimate that it affects 8–16% of the world’s population [1, 2]. It is a major public health problem in Nepal. In 2014, the total death from TB was 1049. e overall treatment success rate (all forms) of drug-susceptible TB was 91%, with 1.1% failure rate, 2% defaulted rate, and 3.3% death rate [5]. e disease frequently leads to hospitalization, significantly increasing the National Health Service cost
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have