Prevalence, Clinical Features, and In-hospital Outcome of Fatty Liver Disease in Acute Aortic Dissection: A Single-Center Retrospective Study.

Yifan Zuo,Zhipeng Hu,Liang Liu,Min Zhang,Yun Xing,Zhiwei Wang,Anfeng Yu,Xin Cai,Zhiyong Wu

doi:10.3389/fcvm.2021.698285

Abstract

Background and Aims: Fatty liver disease (FLD) has emerged as a major public issue in China. We aim to investigate prevalence, clinical features, and in-hospital outcome of FLD in acute aortic dissection (AAD) patients.Methods: Data of 379 AAD patients from 2017 to 2019 at Renmin hospital of Wuhan University was retrospectively collected and divided according to age and FLD absence. Propensity score matching was used for minimal confounding. We compared their physical environmental parameter of onset, clinical features, and in-hospital outcome.Results: The mean age was 52.0 ± 11.5 years in type A and 55.1 ± 11.4 in type B. 25.0% of type A and 19.2% of type B AAD patients had FLD. Logistic regression indicated a negative association between FLD and age, both in type A [unadjusted odds ratio (OR) 0.958 (per 1 year), 95% confidence interval (CI) 0.930–0.988, p = 0.0064] and type B [unadjusted OR 0.943 (per 1 year), 95% CI 0.910–0.978, p = 0.0013]. After matching, type A with FLD had onset with a lower air quality index (AQI) of 68.5 [interquartile range (IQR) 46.0–90.0] and a lower Pm 2.5 concentration of 36.0 μg/m3 (IQR 23.0–56.0) compared with non-FLD group. In Kaplan-Meier estimation, FLD was associated with higher risk of in-hospital mortality in type B AAD (p = 0.0297).Conclusion: The prevalence of FLD in AAD decrease with age, both in type A and type B AAD. Type A AAD patients with FLD had onset with better air quality parameters compared with non-FLD group. FLD was associated with higher risk of in-hospital mortality in type B AAD.

Highlights

Acute aortic dissection (AAD) is a disastrous, life-threatening condition, that can be associated with a very poor outcome
This study aims to investigate the prevalence of fatty liver disease (FLD) in AAD, and compare the clinical features among FLD and non-FLD groups, including in-hospital outcome, physical environmental parameters, and baseline characteristic
One hundred ninety-two type A AAD patients and 187 type B AAD patients with complete medical records were enrolled in the study (Supplementary Figure 1)

Summary

Introduction

Acute aortic dissection (AAD) is a disastrous, life-threatening condition, that can be associated with a very poor outcome. As a consequence of changes in lifestyle and rapid urbanization, fatty liver disease (FLD) has emerged as a major public issue in China, that the prevalence of FLD was 29.2% according to a metaanalysis that used data from a population of 2,054,554 [7]. Despite the potential risk of FLD in cardiovascular diseases (CVD) has been evaluated in numerous studies, there was a paucity of literature that evaluate FLD in aortic diseases, such as AAD. Given the rapid increase in the prevalence of FLD and the potential CVD risk of FLD, further studies to evaluate the prevalence and in-hospital outcome of FLD in AAD remains meaningful. Fatty liver disease (FLD) has emerged as a major public issue in China. We aim to investigate prevalence, clinical features, and in-hospital outcome of FLD in acute aortic dissection (AAD) patients

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