Abstract
BackgroundHuman papillomavirus (HPV) infection is the leading cause of genital diseases. It can cause a series of cervical lesions. The distribution of HPV genotypes indicates that the increased prevalence of high-risk HPV (HR-HPV) is positively correlated with the severity of cervical lesions. In addition, persistent HR-HPV infection is associated with the risk of cervical cancer. Considering the latest approval of homemade HPV vaccine in China and the prevalence of HPV distribution, this is of great significance for guiding HPV vaccination work.ObjectiveOur study’s purpose was to examine trends of cervical HPV infection rate in each 5-year age group from 2011 to 2019.MethodsRetrospective analysis of human papillomavirus prevalence rate of 59,541 women from 2011 to 2019 in the District Zhoupu of Shanghai City in China. HPV genotype testing is performed using a commercial kit designed to detect 15 high-risk HPV genotypes and 6 low-risk HPV genotypes. Trends were examined for each 5-year age group.ResultsIn the District Zhoupu of Shanghai City in China, the prevalence rate of cervical HPV increased significantly among women aged 15–34 years. The most prevalent HR-HPV genotypes were 52, 16, 58, 53, 39, and 51.ConclusionCervical HPV prevalence rate is very high in younger women in suburb Shanghai. Due to significant differences in infection rates between specific age groups and HPV subtypes, timely intervention is required for these vulnerable populations.
Highlights
Cervical cancer is the fourth most common cancer among women worldwide and the fourth leading cause of cancerrelated deaths [1]
Among the 59,541 subjects, 10,670 women were positive for Human papillomavirus (HPV) infection, with a total HPV infection rate of 17.92% (10,670 / 59,541) and a high-risk HPV (HR-HPV) positive rate of 15.56% (9263 / 59,541)
86.81% of the infections were caused by HR-HPV
Summary
Cervical cancer is the fourth most common cancer among women worldwide and the fourth leading cause of cancerrelated deaths [1]. Persistent human papillomavirus (HPV) infection, especially high-risk HPV (HR-HPV) infection, is the main cause of precancerous lesions and cervical cancer [2, 3], and is closely related to cervical and reproductive tract cancers [4]. Some studies have investigated the HPV infection rate and the genotype distribution of Shanghai China in Minhang district [8], female [9] and male [10] patients in the Songjiang district. Human papillomavirus (HPV) infection is the leading cause of genital diseases. It can cause a series of cervical lesions. The distribution of HPV genotypes indicates that the increased prevalence of high-risk HPV (HRHPV) is positively correlated with the severity of cervical lesions. Objective: Our study’s purpose was to examine trends of cervical HPV infection rate in each 5-year age group from 2011 to 2019
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