Abstract
ObjectiveTo evaluate and understand the prevalence of HPV genotypes and characteristics of female populations in specific areas and the relationship with cervical lesions, which can effectively guide cervical cancer screening and formulate HPV vaccine prevention strategies.MethodsA total of 77,443 women who visited gynecological clinics and underwent health examinations in the Second Affiliated Hospital of Zhejiang University School of Medicine during 2016–2020 were enrolled in this survey. Cervical samples were collected for HPV DNA genotyping and cervical cytology testing. Cervical biopsies were performed for patients with visible cervical abnormality or abnormal cytological results.ResultsThe results showed the 5-year overall positive rate was 22.3%, of which the gynecology clinic group had significantly more positive results compared with the health examination group (P < 0.001). The five most common genotypes in Zhejiang Province were HPV 52, 58, CP8304, 16, and 51 (23.9%, 12.7%, 11.7%, 11.7% and 9.3%). HPV infection was age-specific, with the highest infection rate in the age group ≤ 20 compared to other age groups (P < 0.001). HPV infection was also season-specific, with the highest infection rate in spring or winter. The main HPV infection mode was single infection (P = 0.004), but patients ≤ 20 years old were more likely to develop multiple infections (51.0%). HPV 16, 52 and 58 were the main genotypes that caused cytological abnormalities and HPV16, 18, 56, 58 and 66 were independent risk factors for cervical lesions (OR = 2.352, 1.567, 2.000, 1.694, 1.889; all P < 0.05). Further analysis found HPV 16 and 18 were the main genotypes that cause cervical cancer histological abnormalities and were independent risk factors for cervical cancer (OR = 5.647, P < 0.001; OR = 3.495, P = 0.036).ConclusionThis article analyzed the prevalence of distribution characteristics of HPV infection and revealed the corelation between HPV infection and cytological and histological abnormalities. Comprehensive results of this survey will help Zhejiang Province to formulate public health policies and provide evidence for future selection of specific HPV vaccines.
Highlights
As the fourth most common cancer among women worldwide [1], cervical cancer is a significant threat to women
This study aimed to provide a reference for the early prevention, detection, and control of cervical cancer, and a guide for the promotion and application of targeted vaccines for women in Zhejiang Province
Prevalence of human papillomavirus (HPV) infection in health examination group (HEG) and GCGIn total, data was collected from 77,443 HPV screening tests from the HEG (n = 29,216) and gynecological clinic group (GCG) (n = 48,227) between 2016 and 2020
Summary
As the fourth most common cancer among women worldwide [1], cervical cancer is a significant threat to women. There are more than 500,000 new cases of cervical cancer each year. 250,000 women die from cervical cancer every year [2]. Persistent human papillomavirus (HPV) infection is a significant factor in causing cervical cancer [3]. HPV invades the genital tract and is usually categorized as high-risk (HR) or low-risk (LR) genotypes. It is reported that more than 15 HR-HPV genotypes are linked with the development of cervical cancer. HPV 16, 18, 31, 33, 35, 45, 52, and 58 are related to 90% of invasive cervical cancer [4]. LR-HPV genotypes, including HPV 6, 11, 42, 43, and 44 are related to proliferative lesions [5, 6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
