Abstract
TYPE: Abstract Publication TOPIC: Sleep Disorders PURPOSE: Analysis of several prospective populational studies had indicated that those subjects with OSA were more likely to develop cognitive impairment and AD. However, poor is known about the implications of OSA and intermittent hypoxemia in patients with early AD. The aim of this work was to evaluate the prevalence of OSA in patients with a new diagnosis of mild-moderate AD and to evaluate the repercussion on cognitive function. METHODS: We included prospectively 128 subjects with new diagnosis of AD, stratified by their apnea/hypoapnea index evaluated by polysomnography. Subjects were studied by means of a sleep questionnaire that included the Epworth scale and extensive neuropsychological battery RESULTS: Prevalence of OSA was 90,6%. According the severity of OSA, 23% were mild, 29% moderate and 39% severe. The score on the Epworth scale was 5.66, without significant differences between groups (p>0.05). We evaluated the characteristics of cognition according to the severity of OSA. No statistically significant differences were observed. Given oxygen desaturation severity, we observed that patients with severe intermittent hypoxemia showed better cognitive performances in overall items related to verbal memory (Table 1) When we analysed intermittent hypoxia data by gender groups, all differences were observed in female group CONCLUSIONS: High prevalence of no diagnosed OSA in patients with a new diagnosis of AD. This prevalence is not related with an increase of diurnal somnolence. Severe intermittent hypoxemia seems related with a better neuropsychological profile in several cognitive domains. CLINICAL IMPLICATIONS: Maybe, chronic hypoxia throw the phenomenon of ischemic tolerance could have a benefit effect. DISCLOSURE: No significant relationships. KEYWORDS: OSA, Intermittent hypoxia, Alzheimer Disease
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