Abstract
Group B Streptococcus (GBS) is an important perinatal pathogen. It is considered as a leading cause of stillbirth and early onset neonatal infections. The epidemiology of maternal GBS colonization is poorly understood in Tunisia. We investigated genital GBS carriage prevalence and its associated risk factors in pregnant women. Antibiotic susceptibility was evaluated for isolated strains; macrolide gene resistance and capsular serotyping were also performed.
Highlights
Group B Streptococcus (GBS), is a commensal bacterium of gastrointestinal tract and vagina [1]
GBS vaginal colonization is considered as the primary risk factor for neonatal GBS early-onset disease, that’s why CDC guidelines recommend screening by vaginal culture in late pregnancy, with intrapartum antibiotic prophylaxis for carriers [4]
No significant association was observed between candidiasis and gestational diabetes (p = 0.912) or term of pregnancy (p = 0.134)
Summary
Group B Streptococcus (GBS), is a commensal bacterium of gastrointestinal tract and vagina [1]. GBS vaginal colonization is considered as the primary risk factor for neonatal GBS early-onset disease, that’s why CDC guidelines recommend screening by vaginal culture in late pregnancy, with intrapartum antibiotic prophylaxis for carriers [4]. This approach reduced neonatal morbidity and mortality in US with incidence of neonatal GBS sepsis, estimated to 0.41/1000 live births [5]. Group B Streptococcus (GBS) is an important perinatal pathogen. It is considered as a leading cause of stillbirth and early onset neonatal infections. Antibiotic susceptibility was evaluated for isolated strains; macrolide gene resistance and capsular serotyping were performed
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