Abstract
BackgroundHuman papilloma virus (HPV) infection is one of the most common sexually transmitted infections among women worldwide. The current study’s main objective is to report the prevalence and distribution of HPV types in an urban population in Beijing, China.MethodsAll the eligible female participants aged ≥18 years were recruited from the Aerospace Center Hospital in Beijing, China between 2014 and 2018. A total of 21 HPV types were detected by the polymerase chain reaction (PCR) reverse dot blot method and fluorescence quantitative PCR method.ResultsIn total, 12 high risk HPV types and nine low risk HPV types were detected. The HPV-positive rates were 8.85% in 2014, 7.16% in 2015, 7.60% in 2016, 8.31% in 2017, and 7.72% in 2018, respectively, in an urban population in Beijing, China. Overall, no significant differences in the HPV-positive rates were found over the five years. The peak prevalence of HPV infection in all types was observed in age group of 20–24 in all types. HPV52 was the dominant HPV type across the five years . Among all 21 HPV types, HPV66, HPV26, and HPV59 were ranked the top three in coinfection occurrence.ConclusionsOur findings are very helpful for HPV screening and vaccination. The associations between gynaecological diseases and the HPV types with high prevalence, particularly HPV52, warrant further investigation.
Highlights
Human papilloma viruses (HPV) are small groups of double-stranded DNA viruses without enveloped icosahedral capsids (Boda et al, 2018; Zur Hausen, 2002) that cause the most common sexually transmitted infections among women worldwide (Handler et al, 2015; Satterwhite et al, 2013)
The age distribution was similar across every year and the majority of participants were between 30–45 years old
The median age of the participants between HPV (+) and HPV (−) cases were comparable in the five years, respectively (Table 1)
Summary
Human papilloma viruses (HPV) are small groups of double-stranded DNA viruses without enveloped icosahedral capsids (Boda et al, 2018; Zur Hausen, 2002) that cause the most common sexually transmitted infections among women worldwide (Handler et al, 2015; Satterwhite et al, 2013). More than 200 HPV types have been identified (Ghedira et al, 2016) and some had been confirmed to be associated with certain diseases, mainly cancers. The current study’s main objective is to report the prevalence and distribution of HPV types in an urban population in Beijing, China. The HPV-positive rates were 8.85% in 2014, 7.16% in 2015, 7.60% in 2016, 8.31% in 2017, and 7.72% in 2018, respectively, in an urban population in Beijing, China. The associations between gynaecological diseases and the HPV types with high prevalence, HPV52, warrant further investigation
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