Prevalence and Spectrum of Second Primary Malignancies among People Living with HIV in the French Dat'AIDS Cohort.

Isabelle Poizot-Martin,Alain Makinson,Pierre Delobel,Clotilde Allavena,Anne Fresard,Cyrille Delpierre,Teresa Rojas Rojas,Caroline Lions,Sylvie Brégigeon

doi:10.3390/cancers14020401

Abstract

Simple SummaryPeople who survive primary cancers are at an increased risk for subsequent primary cancers. An increased risk for certain types of primary cancers among people living with HIV (PLWH) was demonstrated in the last few decades. Given the increasing life expectancy of PLWH, a steady increase in SPC has been reported. The main objective of this study was to describe the prevalence and spectrum of second primary cancers (SPCs) stratified by first primary cancers in HIV-positive men and women cancer survivors. We showed that the pattern of SPCs differs from that observed in the general population and according to sex. Yet, further studies are needed to determine the excess risk of SPCs in this population and to confirm the need for more appropriate screening procedures.Background: We aimed to describe the prevalence and spectrum of second primary cancer (SPC) in HIV-positive cancer survivors. Methods: A multicenter retrospective study was performed using longitudinal data from the French Dat’AIDS cohort. Subjects who had developed at least two primary cancers were selected. The spectrum of SPCs was stratified by the first primary cancer type and by sex. Results: Among the 44,642 patients in the Dat’AIDS cohort, 4855 were diagnosed with cancer between 1 December 1983 and 31 December 2015, of whom 444 (9.1%) developed at least two primary cancers. The most common SPCs in men were non-Hodgkin lymphoma (NHL) (22.8%), skin carcinoma (10%) and Kaposi sarcoma (KS) (8.4%), and in women the most common SPCs were breast cancer (16%), skin carcinoma (9.3%) and NHL (8%). The pattern of SPCs differed according to first primary cancer and by sex: in men, NHL was the most common SPC after primary KS and KS was the most common SPC after primary NHL; while in women, breast cancer was the most common SPC after primary NHL and primary breast cancer. Conclusion: The frequency and pattern of subsequent cancers among HIV-positive cancer survivors differed according to the first primary cancer type and sex.

Highlights

IntroductionIn France, the risk of second primary cancer (SPC) is on average 36% higher among cancer survivors compared with the general French population [5]
People who survive primary cancers are at an increased risk for subsequent primary cancers, and given the recent progress in the field of therapeutics in oncology, the risk of second primary cancer (SPC) could become a major concern in the near future [1,2,3,4].In France, the risk of SPC is on average 36% higher among cancer survivors compared with the general French population [5]
We aimed to describe the prevalence and the spectrum of SPCs stratified by the type of first primary cancer in HIV-positive men and women in the French Dat’AIDS cohort

Summary

Introduction

In France, the risk of SPC is on average 36% higher among cancer survivors compared with the general French population [5]. In the United States, a 14% increased risk among cancer survivors compared with the general US population was reported [6], with a lifetime risk of developing a SPC estimated to be as high as 33% among selected subgroups of cancer survivors [7]. The pattern of SPCs differed according to first primary cancer and by sex: in men, NHL was the most common SPC after primary KS and KS was the most common SPC after primary NHL; while in women, breast cancer was the most common SPC after primary NHL and primary breast cancer. Conclusion: The frequency and pattern of subsequent cancers among HIV-positive cancer survivors differed according to the first primary cancer type and sex

Objectives

Methods

Results

Discussion

Conclusion