Abstract
BackgroundBenign or malignant lesions caused by Human papillomavirus (HPV) produce considerable health burden worldwide. Since limited cross-protection would be offered between HPV types, heterogeneity in HPV type-specific distribution should be taken into account when predicting the effect of current prophylactic vaccines and forming the basic for the second-generation vaccines targeted to specific regions. Here, we investigated the prevalence of cervical HPV infection, as well as predictors concerned, in Zhejiang Province, southeast China.ResultsTotally 4987 cervical samples from five randomly chosen counties in Zhejiang Province were detected. The overall HPV prevalence was 13.3%. Established high-risk (HR) HPV prevalence was 10.2%. HPV-52 was the most prevalent type (3.1%), followed by HPV-16 (2.5%), -58 (2.1%), -68 (1.0%) and -81 (0.9%). HPV-16 or -18 were present in 3.1% of the detected samples, while 174 specimens (3.5%) were positive for any of HPV-6, -11, -16 and -18. The prevalence of HPV vaccine types was consistently low across age groups. Bimodal age distribution in HR-HPV, including established HR and probably HR-HPV, was observed, with a clear second peak in perimenopausal women. Multivariate unconditional logistic regression models revealed that partner's lifetime number of partners was the only common independent predictor of overall, established HR, established low-risk, single-type and multiple-type HPV infection in current study.ConclusionsWe have observed low prevalence of HPV vaccine types and relatively high prevalence of HPV-52 and -58 in our population. Our findings support universal "catch-up" vaccination of sexual experienced young women in Zhejiang Province, as well as enhance the hypothesis that the second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women in China and other Asian areas. Furthermore, our data support close surveillance of perimenopausal women with HR-HPV infection.
Highlights
Benign or malignant lesions caused by Human papillomavirus (HPV) produce considerable health burden worldwide
Since limited cross-protection would be offered between HPV types [9], heterogeneity in HPV type-specific distribution from different populations should be taken into account when predicting the effect of current prophylactic vaccines [10] and forming the basic for the second-generation vaccines targeted to specific regions
Due to the feasible anatomic site for sampling and the well-established sampling method for cervix, here, we investigated the cervical HPV infection in asymptomatic general female population to be conscious of the overall, type-specific and age-specific HPV prevalence, as well as determinants of HPV infection, in Zhejiang Province before large scale vaccination programs occur
Summary
Benign or malignant lesions caused by Human papillomavirus (HPV) produce considerable health burden worldwide. HPV has been shown to be the etiologic agent of anogenital, especially cervical, cancers and a fraction of oropharyngeal. Both the two available prophylactic HPV vaccines, the bivalent vaccine (Cervarix®, GlaxoSmithKline Biologicals, targeted at HPV-16 and -18) and the quadrivalent vaccine Since limited cross-protection would be offered between HPV types [9], heterogeneity in HPV type-specific distribution from different populations should be taken into account when predicting the effect of current prophylactic vaccines [10] and forming the basic for the second-generation vaccines targeted to specific regions
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