PREVALENCE AND RISK OF REPRODUCTIVE DISORDERS IN DESCENDANTS DEPENDING ON GRANDPARENT’S IRRADIATION

Abstract

The main objective of the observational, analytical, one-stage (cross-sectional) study was to determine the prevalence of reproductive disorders depending on who of the grandparents had been exposed to radiation (grandmother, grandfather or both). Methods. On the basis of the results of clinical and paraclinic data, a multistage mathematical analysis was carried out which allowed to trace the influence of radiation factor on the reproductive health of descendants. The main group included 67 women of the second generation of descendants, who were divided into three subgroups according to the criteria of radiation exposure: on grandfather (17 people); on grandmother (28) and on the both (22). The control group included the descendants of people living outside the zone of Semipalatinsk Test Site radiation track (53 women). Results. On the basis of mathematic modelling it was shown, that by maternal inheritance or inheritance from both grandparents, descendants of second generation showed the increase in frequency of menstrual disorders (F = 4.761; р = 0.01), fertility reduction (F = 7.155; р = 0.001), increase of high-risk pregnancy (F = 13.705; р = 0.001), premature birth (F = 5.350; р = 0.01), low birth weight (F = 6.221; р = 0.001). inclusions. Matriliny and patriliny allows one to predict the deterioration of reproductive health in the next (third) generation of offspring.