Prevalence and risk factors of sexual dysfunction in patients with Parkinson's disease

Abstract

Objective To investigate the prevalence and related factors of sexual dysfunction (SD) in patients with Parkinson's disease. Methods A total of 411 patients with Parkinson' disease in Nanjing Brain Hospital were analyzed retrospectively. The ICD-10 diagnostic criteria for SD was used to evaluate SD.The Unified Parkinson's Disease Rating Scale (UPDRS) part Ⅲ, Hoehn and Yahr (H&Y) staging, Non-motor Symptoms Questionnaire (NMS-Quest), Parkinson's Disease Sleep Scale (PDSS), Hamilton Anxiety Rating Scale (HAMA), Hamilton Rating Scale for Depression (HRSD) and Montreal Cognitive Assessment (MoCA) were used to evaluate patients. Results SD was found in 145(35.3%) patients and the prevalence was higher in male than in female. Patients with SD had older age, longer duration, severer motor symptoms, and higher scores of UPDRS-Ⅲ, HAMD, HAMA and NMS-Quest (all P<0.05). In male patients, SD was positively associated with age, duration of disease, UPDRS-Ⅲ, H-Y stage, HAMD, HAMA and NMS (r=0.127, 0.303, 0.240, 0.236, 0.181, 0.221 and 0.302, all P<0.05). In female patients, SD was positively associated with duration of disease, HAMD, HAMA and NMS (r=0.194, 0.163, 0.189 and 0.178, all P<0.05). The forward binary Logistic regression analysis indicated that female gender (OR=0.539, P<0.05), duration of disease (OR=1.133, P<0.05), NMS (OR=1.104, P<0.05) and history of exposure to heavy metals (OR=5.268, P<0.05) were associated with SD. Conclusions SD is a common complication in patients with Parkinson's disease, and a great attention should be paid to its screening and diagnosis. Key words: Parkinson disease; Sexual dysfunction, physiological; Questionnaire