Abstract
Background: The global burden of chronic degenerative disease is increasing worldwide. Most developing countries have dual burden with infectious and non-infectious diseases. Kidney disease is a long term health condition and defined as the gradual loss of body, renal function and death over time. Renal abnormalities were quite prevalent in rheumatoid arthritis patients and there is a significant increase of renal derangement with duration of disease and severity of disease activity. Methods: A hospital based cross-sectional study was conducted. Blood sample was collected for assessment of urea and creatinine. Urine sample was also collected for protein and blood detection. Serum creatinine was analyzed by an automated biochemistry machine Mindray 200 BS. Urine protein and blood was detected by chemical test. Descriptive, bivariate and multivariate analyses were used to analyze the data. Odds ratio with 95%CI was estimated to assess the predictors of renal impairment. Result: Out of 219 rheumatoid arthritis patients, 49 (22.4%) had renal impairment. Serum creatinine level in mg/dl of the patients were with mean and standard deviation (SD) of (1.67 ± 0.47 SD) with adjusted odd ratio (AOR) and (95%CI):14.07 (5.09, 38.91), Mean (± SD) age of the participants was 43.82 (± 14.03) years and about 75.3% were females. Protienuria 44 (20.1%) with AOR (95%CI):1.93 (1.68, 5.58) and Body Mass Index (BMI) above 25 with AOR (95%CI): 0.1 (0.02, 0.45) shows significant association with the prevalence of renal impairment. Conclusion: The study revealed that the prevalence of renal impairment in patients’ with rheumatoid arthritis is high. Screening for renal impairment for patients with rheumatoid arthritis will be very helpful to peak kidney disease at earlier stage.
Highlights
The global burden of chronic degenerative disease is increasing worldwide
As age increases there is a gradual decrement in the nephrons number and associated decline in glomerular filtration rate
This study indicates that the prevalence of renal impairment among study participants was high
Summary
The global burden of chronic degenerative disease is increasing worldwide. Among those, kidney disease is an increasing global health problem [1]. According to World Health Organization’s report, 2003, the prevalence of impaired kidney function was estimated to range between 10% to 20% of the adult population in most countries worldwide [3,4]. Chronic kidney disease is reported to be 3-4 times more common in Africa than in developed countries [6]. The incidence of chronic kidney disease in Ethiopia is rising because of increased risk factors such as rheumatoid arthritis, high blood pressure and diabetes mellitus [7,8]. The global burden of chronic degenerative disease is increasing worldwide. Kidney disease is a long term health condition and defined as the gradual loss of body, renal function and death over time. Renal abnormalities were quite prevalent in rheumatoid arthritis patients and there is a significant increase of renal derangement with duration of disease and severity of disease activity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
