Prevalence and risk factors of osteoporosis in Chronic Obstructive Pulmonary Disease (COPD) patients from Central India.

Abstract

The prevalence of osteoporosis in patients with COPD is high and potentially essential. To study prevalence and various risk factors contributing to osteoporosis in COPD patients. The present study is prospective cross sectional study carried out on 80 stable COPD patients attending tertiary care hospital in central India. After taking written consent & detailed clinical history consisting questionnaire about the risk factors, spirometry was done to stage the severity of COPD. DEXA scan of whole body was performed using fan beam X-ray bone densitometer to determine osteoporosis. Chi-square test was used to determine the association between COPD and osteoporosis. Univariate logistic regression was used to analyze the risk factors for developing osteoporosis. In the present study, the overall prevalence of low BMD was found to be 92.5% in COPD patients showing equal prevalence (46.25%) for osteoporosis and osteopenia. The duration & severity of disease along with steroid intake were found to be risk factors of osteoporosis in univariate analysis with risk ratio of 1.32 (95% CI 1.06-1.64), 1.75 (1.11-2.75) and 1.40 (1.00-1.97) respectively (p value <0.05). The prevalence of low BMD was very high in COPD patients at a tertiary care hospital of central India. Duration & severity of disease along with steroid intake were found to be risk factor for osteoporosis in univariate analysis.