Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China.

Hongbin Li,Meihao Guo,Jun Meng,Jing Jiang,Jie Song,Zhen An,Weidong Wu

doi:10.3390/ijerph17061818

Abstract

Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence worldwide is increasing, and tremendous challenges in controlling this pandemic are arising. The objective of this study was to investigate the prevalence and risk factors of MAFLD in rural areas of Xinxiang, Henan in 2017. We conducted a cross-sectional analysis of rural inhabitants aged 20–79 years in Xinxiang, Henan in 2017, using cluster random sampling (N = 9140). Physical examinations were conducted at local clinics from April to June 2017. After overnight fasting, all participants underwent physical examinations, blood routine tests, biochemical examinations, and liver ultrasound and completed questionnaires. We investigated the crude and age-adjusted MAFLD prevalence and analyzed the characteristics of those with, and without, MAFLD, using logistic regression. Approximately 2868 (31.38%) participants were diagnosed with MAFLD. The overall age-adjusted MAFLD prevalence was 29.85% (men: 35.36%; women: 26.49%). The MAFLD prevalence increased with age, and peaked at the 50–59-year age group, and then began to decline. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were independently and positively correlated with MAFLD; In contrary, active physical activity and high-density lipoprotein cholesterol were negatively correlated with MAFLD. In summary, the MAFLD prevalence in the study population was 29.85%. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were risk factors for MAFLD.

Highlights

Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility [1].Obesity, Type 2 diabetes mellitus (DM), and metabolic syndrome are consistently identified as the most important risk factors for MAFLD [2].With rapid lifestyle transitions, the prevalence of MAFLD worldwide is thought to be increasing [3].Its prevalence in mainland China was 29.81% (27.78–31.93%), while the prevalence in Taiwan wasInt
The prevalence of MAFLD gradually increased with Body mass index (BMI) (Table 1)
The analysis revealed that BMI, waist circumference, LYMPH%, HGB level, PLT level, ALT level, TG level, fasting plasma glucose (FPG) level, and serum uric acid (SUA) level were independently and positively correlated with the presence of MAFLD; in contrary, active physical activity and high-density lipoprotein cholesterol (HDL-C) level were independently and negatively correlated with the presence of MAFLD

Summary

Introduction

Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility [1].Obesity, Type 2 diabetes mellitus (DM), and metabolic syndrome are consistently identified as the most important risk factors for MAFLD [2].With rapid lifestyle transitions, the prevalence of MAFLD worldwide is thought to be increasing [3].Its prevalence in mainland China was 29.81% (27.78–31.93%), while the prevalence in Taiwan wasInt. Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility [1]. Type 2 diabetes mellitus (DM), and metabolic syndrome are consistently identified as the most important risk factors for MAFLD [2]. The prevalence of MAFLD worldwide is thought to be increasing [3]. Its prevalence in mainland China was 29.81% (27.78–31.93%), while the prevalence in Taiwan was. Res. Public Health 2020, 17, 1818; doi:10.3390/ijerph17061818 www.mdpi.com/journal/ijerph

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