Prevalence and risk factors of lower urinary tract symptoms in Chinese adult men: a multicentre cross-sectional study.

Huangtao Guan,Honggang Li,Wei Xia,Yi Zheng,Chengliang Xiong,Huangfang Shangguan,Changhong Zhu,Meng Rao,Huiping Zhang,Zhengyan Zeng

doi:10.18632/oncotarget.22378

Abstract

There has been no previous population-based study reporting the prevalence and risk factors of male lower urinary tract symptoms (LUTS) among men in mainland China. This cross-sectional study was conducted from 2013 to 2014 in three representative provinces of China: Guangdong, Hubei and Jiangsu. 3250 individuals participated in the interviews, which involved a questionnaire covering sociodemographic characteristics, lifestyle, dietary patterns and the International Prostate Symptom Score (IPSS). Blood was collected for lipids, glucose, insulin and reproductive hormone tests. The incidences of LUTS and its obstructive and irritative symptoms were calculated. Risk factors for LUTS were identified using multivariable logistic regression analysis. The prevalence of moderate to severe LUTS and its obstructive and irritative symptoms was 14.3%, 13.1% and 16.1%, respectively, and increased with age. The prevalence in Guangdong was much lower than that in Hubei and Jiangsu in different ages. Increased fasting plasma glucose and decreased HDL-C levels were associated with an increased risk of moderate to severe LUTS (OR = 1.30, 95% CI: 1.02–1.65 and OR = 2.06, 95% CI: 1.08–3.94, respectively). Free testosterone < 0.22 ng/ml decreased the risk of moderate to severe LUTS and obstructive and irritative symptoms by about 20–30%. An inadequate daily intake of vegetables, fruit and water significantly increased the risk of LUTS by 1.3–to 2.0 times. In conclusion, the prevalence of LUTS in Chinese men is high and increases with age. Dietary patterns may be critical for the development of LUTS. Thus, dietary modifications could be a useful strategy for preventing the development of LUTS.

Highlights

Lower urinary tract symptoms (LUTS) is one of the most common clinical complaints in elderly men and has a significant effect on their quality of life [1]
Only men who ate almost no fruit experienced a 1.7- to 2.0 times increased risk of moderate to severe lower urinary tract symptoms (LUTS) (OR = 1.67, 95% CI, 1.05, 2.65) and obstructive symptoms (OR = 1.98, 95% CI, 1.20, 3.27), respectively, compared with men who ate more than 200 g of fruit per day. This is the first multicentre study aimed at investigating the prevalence and risk factors of LUTS in Chinese men
These studies used International Prostate Symptom Score (IPSS) to evaluate the risk of LUTS and took total IPSS scores > 7 to indicate moderate to severe LUTS

Summary

Introduction

Lower urinary tract symptoms (LUTS) is one of the most common clinical complaints in elderly men and has a significant effect on their quality of life [1]. LUTS is a cluster of chronic urinary symptoms in the bladder, prostate or urethra, and a major cause of benign prostatic hyperplasia (BPH) [2]. There has been no populationbased study of LUTS in mainland China, except for two investigations conducted in Hong Kong [11, 12]. While the identification of risk factors is important for the prevention of LUTS, apart from advancing age, there have been inconsistent conclusions about what may constitute a risk. Some studies have reported alcohol and cigarette consumption as an important risk factor for www.impactjournals.com/oncotarget

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