Abstract
BackgroundIn this study, we aimed to determine the prevalence and risk factors of low anterior resection syndrome (LARS) in epithelial ovarian cancer (EOC) surgery.MethodologyA descriptive cross-sectional study was conducted at the Gynecologic Oncology Section of the Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan. Using non-probability consecutive sampling technique, all patients who underwent cytoreductive surgery involving low anterior resection for EOC between January 2016 and January 2021 were included. Patients were assessed for LARS symptoms using the LARS score, along with its risk factors. Descriptive statistics, that is, continuous variables were expressed as the median and interquartile range, while categorical variables were expressed as frequencies and percentages. The LARS score was categorized according to a two-tier model with “no or minor LARS” and “major LARS.” Univariate analyses were performed by the chi-square tests providing odds ratios and 95% confidence intervals to identify risk factors for major LARS.ResultsOverall, 95% of cases had LARS scores that fell in “no or minor LARS,” while only 5% of cases had “major LARS.” Univariate analyses relieved no statistically significant association between the occurrence of major LARS and any of the risk factors.ConclusionsThe prevalence of LARS was 5%, and no risk factors were associated with major LARS in our study population.
Highlights
Ovarian cancer is the most common cause of cancer death from gynecologic tumors [1]
The prevalence of low anterior resection syndrome (LARS) was 5%, and no risk factors were associated with major LARS in our study population
To fulfill the surgical goal of R1 resection, that is, no macroscopic residual disease, cytoreductive surgery (CRS) often includes bowel resection, including low anterior resection of the rectum. It is a frequent component of CRS for advanced epithelial ovarian cancer (EOC), and additional bowel resections are sometimes required
Summary
Ovarian cancer is the most common cause of cancer death from gynecologic tumors [1]. Malignant ovarian tumors include primary ovarian cancer and secondary metastatic ovarian cancer. An essential part of the treatment of EOC is cytoreductive surgery (CRS) aiming at complete tumor resection [4,5]. To fulfill the surgical goal of R1 resection, that is, no macroscopic residual disease, CRS often includes bowel resection, including low anterior resection of the rectum. It is a frequent component of CRS for advanced EOC, and additional bowel resections are sometimes required. Among long-term complications, low anterior resection syndrome (LARS) is a serious and common complication that affects the quality of life (QoL) of patients. We aimed to determine the prevalence and risk factors of low anterior resection syndrome (LARS) in epithelial ovarian cancer (EOC) surgery
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