Prevalence and risk factors of latent tuberculosis infection in adolescent in Islamic boarding schools

Abstract

Latent tuberculosis infection (LTI) is an obstacle in eradicating pulmonary tuberculosis. 5-10% people with LTI will develop into active tuberculosis (TB) in the first 5 years after the first TB infection. Islamic boarding schools are a highly potential area in increasing LTI incidents in adolescents. Existing studies are mostly focused on reporting LTI in the general population. To determine the prevalence and risk factors of LTI in adolescents in islamic boarding schools in Bangkalan Madura. A cross sectional study was conducted at the Islamic Boarding School Bangkalan Madura in January 2022 using a random sampling technique. The IGRA examination using the QIAreach QuantiFERON TB tool. The risk factors analyzed include age, gender, nutritional status, TB contact history, duration of stay in Islamic boarding schools and level of knowledge. The data obtained were further analyzed using chi-square and logistic regression test. A total of 100 subjects were examined by IGRA resulting in 30 positive subjects consisting of 30.3% male and 29.9% female. TB contact history (OR 5.167; 95% CI = 1.831-14.567; p=0.002) and level of knowledge about TB (OR 0.019; 95% CI = 0.005-0.069; p<0.05) are significantly related to the incidence of LTI in adolescents in islamic boarding schools.