Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), which is endangering human health worldwide, especially in Africa, Europe, the United States, and parts of Asia. The aim of this study was to investigate the prevalence of KSHV in Xinjiang. Three KSHV recombinant proteins (ORF65, ORF73, and K8.1) were used to detect KSHV infection. The serum samples to be tested were detected by an indirect ELISA method. The overall infection rate of KSHV in Xinjiang was 25.60%, with a higher infection rate in the Uygur population of 29.79%. After adjusting for possible confounders, Uygur (OR = 3.95, 95% CI 2.64–6.12, P < 0.001), agriculture and livestock (OR = 1.60, 95% CI 1.20–2.17, P = 0.002), age ≤ 50 years (OR = 1.50, 95% CI 1.13–2.00, P = 0.006), and predominantly meat-based diet (OR = 1.72, 95% CI 1.11–2.78, P = 0.018) were significantly associated with the odds of KSHV seropositivity correlation. Three unique sequences of KSHV were obtained in this study; genotypic analysis showed that the three unique sequences were all subtype A2.
Highlights
Kaposi’s sarcoma-associated herpesvirus (KSHV), known as human herpesvirus type 8 (HHV-8), [1, 2] belongs to the family of gamma herpesviruses
[3] KSHV is the etiology of primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). [1, 4,5,6] Previous studies have shown that KSHV has a global distribution, mainly in Africa, with seroprevalence greater than 40%. [7, 8] KSHV seroprevalence is less than 10% in the Americas, [9, 10] whereas in parts of Asia and Europe, the seropositivity rate for KSHV is between 10% and 20%. [11, 12]
[20] According to the polymorphism of K1 gene, KSHV is mainly classified into A, B, C, D, E, and F subtypes. [20,21,22] Among them, the subtype A of KSHV was most commonly found in North America and was mainly prevalent in patients with typical KS; subtype B was unique to Africa; subtype C was mainly distributed in the Mediterranean, Middle East and Asia; subtype D was characteristic of people from Japan, Southeast Asia, and some Pacific islands; and subtype E was mainly distributed in Brazil of South America. [23,24,25] e geographical clustering of KSHV appeared to be linked to the movements of ancient infected populations. [26]
Summary
Kaposi’s sarcoma-associated herpesvirus (KSHV), known as human herpesvirus type 8 (HHV-8), [1, 2] belongs to the family of gamma herpesviruses. It was first discovered in 1994 by Chang and Moore in the tissues of Kaposi’s sarcoma. [1, 4,5,6] Previous studies have shown that KSHV has a global distribution, mainly in Africa, with seroprevalence greater than 40%. Previous studies have shown that the prevalence of KSHV infection in the general population in Xinjiang is between 19.20% and 35.40%. Xinjiang is inhabited by the Uygur and Han populations, and the risk factors for KSHV in the region are not well understood, and the potential risk factors for KSHV infection have not been fully assessed. e aim of this study was to investigate the seroprevalence of KSHV among different ethnic groups in the region and to assess the relationship between KSHV prevalence and the relationship between demographic factors and everyday behavior
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Schedule a callMore From: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
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