Prevalence and risk factors of hallucination in patients with Parkinson disease

Abstract

Objective To investigate the prevalence and risk factors of hallucination in patients with Parkinson disease(PD)，and to analysis the relationship between hallucination and different types of PD. Methods We recruited 163 patients with PD from outpatient department in Beijing Tiantan Hospital. The subjects were divided into two groups， the hallucination group and the non­hallucination group. We assessed both the two groups respectively with UPDRS， Hohen­Yahr rank， Hamilton Depression Scale(HAMD)， Pittsburgh Sleep Quality Index(PSQI)， Fagitue Severity Scale(FSS)， Parkinson fatigue scale(PFS)，Mini­Mental State Examination(MMSE) and Montreal Cognitive Assessment (MoCA). Then we compared the difference between the two groups， statistical cluster analysis was used to study the relationship between heterogeneity and hallucination. Results In our 163 patients with PD， 20 of them (12.27%) had hallucination. The hallucination and non­hallucination groups had no difference in sex， age， age of onset， duration of illness， long­term complications and the scores of UPDRS， PSQI， FSS， PFS， MMSE and MoCA (P>0.05). The proportion of dyskinesia (35.0%) in hallucination group was significantly higher than that (9.1%) in the non­hallucination group. There were also significant differences in scores of postural stability， H­Y， UPDRS I， UPDRS II， HAMD and Levodopa Equivalents between the two groups. Logistic regression revealed that depression was the independent risk factor for hallucination in PD patients.