Prevalence and Risk Factors for Undiagnosed Glucose Intolerance Status in Apparently Healthy Young Adults Aged

Young Sang Lyu,Sang Yong Kim,Hak Yeon Bae,Jin Hwa Kim

doi:10.3390/ijerph16132393

Abstract

Background: Early-onset diabetes results in longer lifetime hyperglycemic exposure that consequently leads to earlier chronic diabetes complications and premature death. The aim of this study was to quantify the prevalence and risk factors of undiagnosed diabetes and undiagnosed prediabetes in apparently healthy young adults aged <40 years. Methods: This study used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional, nationally representative survey conducted by the Korean Ministry of Health and Welfare from 2014 to 2017. A total of 4442 apparently healthy young adults enrolled in this study. Multivariate logistic regression analyses were conducted separately to evaluate associated risk factors with undiagnosed diabetes and undiagnosed prediabetes in groups stratified by sex. Results: The prevalence of undiagnosed diabetes and undiagnosed prediabetes was 1.2% and 25.0%, respectively. Obesity (body mass index ≥ 30.0 kg/m2) was a significant risk factor of undiagnosed diabetes regardless of sex (men, odds ratio (OR): 9.808, 95% confidence interval (CI): 1.619–59.412; women, OR: 7.719, 95% CI: 1.332–44.747). Family history of diabetes was significantly associated with undiagnosed diabetes (OR: 3.407, 95% CI: 1.224–9.481) in women only. Increased age, obesity status, and family history of diabetes were significant risk factors for undiagnosed prediabetes. Alcohol consumption was found to be negatively associated with undiagnosed prediabetes in women. Conclusions: Increased attention and implementation of precise strategies for identifying young adults at high risk for undiagnosed diabetes would allow for increased wellbeing as well as reduced healthcare burdens associated with diabetes.

Highlights

Increased incidence of diabetes has resulted in an increased prevalence of diabetes in young adults.Data from the International Diabetes Federation showed a dramatic global increase in young adults aged 20–39 years with type 2 diabetes from 23 million cases in the year 2000 to 63 million in 2013 [1].Early-onset diabetes results in an overall longer lifetime hyperglycemic exposure, which can lead to earlier chronic diabetes complications and an increased risk of later life cardiovascular disease (CVD) development [2,3]
Age at first diabetes diagnosis is associated with loss of life years and is higher for those diagnosed with diabetes at a younger age (20.0 life-years lost for those diagnosed at 20 years, 10.6 life-years lost for those diagnosed at 40 years, and 4.5 life-years lost for those diagnosed at 60 years) [4]
This study found that obesity was significantly associated with an increased risk of undiagnosed diabetes or undiagnosed prediabetes in young adults

Summary

Introduction

Early-onset diabetes results in an overall longer lifetime hyperglycemic exposure, which can lead to earlier chronic diabetes complications and an increased risk of later life cardiovascular disease (CVD) development [2,3]. Early-onset diabetes results in longer lifetime hyperglycemic exposure that leads to earlier chronic diabetes complications and premature death. The aim of this study was to quantify the prevalence and risk factors of undiagnosed diabetes and undiagnosed prediabetes in apparently healthy young adults aged

Objectives

Methods

Discussion

Conclusion