Abstract
ObjectivePeripheral neuropathies (PNs) are a group of disorders that affect the peripheral nervous system. PN in gout has been scarcely described. This study is conducted to determine the prevalence and related risk factors of PN, as assessed by vibration perception threshold (VPT) in patients with gout.MethodsA total of 442 patients were included in the cross-sectional study. The VPT values were measured by using the Biothesiometer sensory quantitative tester on each patient. The VPT value of either limb higher than 15 V was considered abnormal and is considered to have PN. The univariate and multivariate logistic regression models were used to identify risk factors for PN in patients with gout.ResultsWe included 442 patients with gout, 97.5% men, 26.9% tophaceous gout, mean age 45.5 ± 15.2 years, and 7.4 ± 4.6 years of disease duration. The prevalence of PN in patients with gout was 11.1%. Patients in the abnormal VPT group were older, had a longer gout duration, and had significantly higher levels of waist circumference, waist-to-hip ratio, systolic blood pressure (SBP), and erythrocyte sedimentation rate (ESR), as compared to patients in the normal vibration group (P < 0.05). The univariate logistic regression analysis demonstrated that there was a significant association between abnormal VPT and age, duration of gout, SBP, C-reactive protein, ESR, presence of tophi, and estimated glomerular filtration rate (eGFR) in all the subjects (P < 0.05). The multivariate logistic regression analysis indicated that age (odds ratio, 1.094) and presence of tophi (odds ratio, 1.048) were independent risk factors for PN in patients with gout.ConclusionThe abnormal VPT was significantly correlated with age and presence of tophi in patients with gout and the VPT level may be useful as a screening tool for assessment of PN in gout.
Highlights
Gout is the most prevalent inflammatory arthritis in the world
Patients were divided into the two groups by vibration perception; the prevalence of Peripheral neuropathies (PNs) (VPT > 15 V) in patients with gout was 11.1%
The prevalence of the abnormal vibration perception threshold (VPT) group was higher in progressively increasing age categories and was markedly higher in patients with gout with tophi than in those without tophi
Summary
Gout is the most prevalent inflammatory arthritis in the world. A meta-analysis of 30 studies published from 2000 to 2016 found a pooled prevalence of gout in the adult population in China of 1.1% [1]. A thorough understanding of the complications of gout and early prevention and treatment are very important to improve the quality of life of patients. PN is more common in patients with diabetes mellitus, vitamin deficiencies, amyloidosis, alcohol abuse, uremia, infectious and autoimmune diseases, and exposure to environmental toxins. Several observational studies suggest that hyperuricemia is associated with PNs including chronic inflammatory demyelinating polyneuropathy (CIDP) [7], diabetic sensorimotor polyneuropathy [8], and in healthy subjects [9]. To the best of our knowledge, epidemiological data regarding the prevalence of PN in patients with gout have been scarcely described. There are several reports of compression neuropathy, especially carpal tunnel neuropathy, due to hyperuricemia (gout) in which tophaceous deposits were found at surgery
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