Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset Type 1 and Type 2 Diabetes

Abstract

AimTo assess the prevalence and risk factors for diabetic retinopathy (DR) in people with young onset type 1 (T1DM-Y) and type 2 diabetes (T2DM-Y). MethodsT1DM-Y(n=150) and T2DM-Y(n=150) participants, age between 10 and 25 years at diagnosis, had a complete clinical evaluation, biochemical assessment, and four field digital retinal colour photography. The Early Treatment Diabetic Retinopathy Study grading system was used to grade DR. Proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) were considered as sight threatening DR. ResultsThe prevalence of any DR was 53.3% [95% CI 45.3–61.3] in T1DM-Y (duration of diabetes: 12.4±7.4years) and 52.7% [44.7–60.7] in T2DM-Y (11.8±8.3years). The age and gender adjusted prevalence of DR, DME and PDR was 62.5%, 10% and 7.3% in T1DM-Y, whereas it was 65.8%,12.7% and 9.3% in T2DM-Y respectively. In multivariable logistic regression, diabetes duration [Odds ratio (OR) 1.99 per 5years; CI 1.42–2.79], waist circumference [1.28 per 5cm;1.05–1.56] and microalbuminuria [2.39 per 50μg;1.07–5.31] were associated with DR in T1DM-Y, and diabetes duration [2.21 per 5years; 1.61–3.02], diastolic blood pressure [1.54 per 5mmHg;1.18–2.02], Glycated hemoglobin [1.37 per %;1.07–1.75] and lower stimulated C-peptide [1.54 per 0.5pmol/ml;1.15–2.05;] were associated with DR in T2DM-Y. ConclusionOver half of the people with young-onset diabetes, regardless of type, have retinopathy within 10–12years of diabetes duration, emphasizing the need for regular eye screening and aggressive control of glucose and blood pressure to prevent DR.