Abstract
BackgroundEarly and prompt diagnosis of urinary tract infection (UTI) in neonates has important therapeutic implications. The aim of this study was to evaluate the prevalence of UTI in neonates admitted to a referral neonatal intensive care unit (NICU) and to identify predictors associated with an increased risk of UTI in NICU population.ResultsThe prevalence of culture-proven UTI in the studied neonates was 6.67%. Moreover, UTI was more frequent (70%) among full-term neonates. Additionally, both fever and pyuria were the only clinical and laboratory findings that showed significant association with UTI (p < 0.05). Binary logistic regression revealed that neonates with pyuria in urine analysis were 5.44 times more liable to have UTI, while the presence of fever constitutes a risk of only 0.166 (odds ratios were 5.44 and 0.166, respectively). Additionally, sensitivity, specificity, positive predictive value, and negative predictive value of the regression model were 50.0, 94.5, 20.05, and 98.57%, respectively.ConclusionsWe conclude that UTI is not uncommon in full-term neonates admitted in NICU. Additionally, pyuria was significantly related to positive urine culture and its detection in urine analysis increases the likelihood of UTI by 5.44 times.
Highlights
And prompt diagnosis of urinary tract infection (UTI) in neonates has important therapeutic implications
This study was conducted on 150 newborns admitted to neonatal intensive care unit (NICU) who fulfilled the eligibility criteria during the study period
Lower incidence (1–2.4%) of UTI was reported among asymptomatic term neonates who were not admitted to NICU [14]
Summary
And prompt diagnosis of urinary tract infection (UTI) in neonates has important therapeutic implications. Prevalence of urinary tract infection (UTI) among full-term neonates has been reported to be up to 1.1%. This figure increased up to 7% among those with fever [1], whereas the incidence of neonatal UTI varies from 0.1 to 1% of all infants. The assumed complications of sterile catheterization or suprapubic aspiration hinder urine collection, and Characterization of UTI in neonates is very essential. It may be the first indicator of underlying abnormalities of kidneys and the urinary tract. The early discovery and the early proper intervention are crucial in minimizing sequel of these anomalies [4]
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