Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study.

Rong Li,Dongzi Yang,Geng Yu,Shangwei Li,Xiuxia Wang,Zhaolian Wei,Shulan Lu,Xueru Song,Shuxin Fu,Jie Qiao,Xiaoke Wu

doi:10.1186/1472-6823-14-76

Abstract

BackgroundPolycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This study aimed to determine the prevalence and predictors of the metabolic abnormalities in Chinese women with and without PCOS.MethodsA large-scale national epidemiological investigation was conducted in reproductive age women (19 to 45 years) across China. 833 reproductive aged PCOS women, who participated in the healthcare screening, were recruited from ten provinces in China. Clinical history, ultrasonographic exam (ovarian follicle), hormonal and metabolic parameters were the main outcome measures.ResultsThe prevalence of metabolic syndrome (MetS) as compared in PCOS and non-PCOS women from community were 18.2% vs 14.7%, and IR (insulin resistance) were 14.2% vs 9.3% (p < 0.001) respectively. After adjusting for age, the indicators (central obesity, hypertension, fasting insulin, SHBG, dyslipinaemia) for metabolic disturbances were significantly higher in PCOS than in non-PCOS groups. Using multivariate logistic regression, central obesity and FAI were risk factors, while SHBG was a protective factor on the occurrence of Mets and IR in PCOS women (OR: 1.132, 1.105 and 0.995).ConclusionsThe risk factors of the metabolic syndrome and insulin resistance were BMI and FAI for PCOS women, respectively. The decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance.

Highlights

Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients
Compared women without PCOS, those with PCOS were younger, but there was no difference in central obesity as measured by Waist to hip ratio (WHR)
In the present study, a large-scale national epidemiological investigation was conducted in reproductive age women (19 to 45 years) across China, and total 833 reproductive aged PCOS women who were accordance with the established criterions participated from ten provinces in China

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This study aimed to determine the prevalence and predictors of the metabolic abnormalities in Chinese women with and without PCOS. Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.6% of Chinese women of reproductive age [1,2]. Based on the Adult Treatment Panel III criteria [4], the prevalence of metabolic syndrome (MetS) has been previously reported to be 1.6% [5], 8.2% [6] and 43% [7] in Czech, Italian and US women with PCOS, and 24.9% in Chinese Hongkong women [8]. Some evidence suggested that women with PCOS had a greater predisposition to obesity

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