Abstract
Aim: To describe treatment-induced toxicities (TITs) and associated factors in Zimbabwean cancer patients receiving cisplatin. Methods: In total, 252 Zimbabwean women with cervical cancer, receiving cisplatin were followed up over 12months for TITs and disease status. Results: Peripheral neuropathy (70%) and ototoxicity (53%) were most prevalent. Advanced disease (OR=1.3; 95% CI=1.1-1.5; p=0.02), pain comedications (OR=1.3; 95% CI=1.1-1.5; p=0.03), alcohol (OR=2.8; 95% CI=1.1-7.5; p=0.04) and comorbidities (OR=1.2; 95% CI=1.1-1.4; p=0.04) increased peripheral neuropathy and ototoxicity risk. Older age increased risk of disease progression (OR=1.9; 95% CI=1.4-3.0; p=0.033). Conclusion: High peripheral neuropathy and ototoxicity prevalence were observed, which are not routinely monitored in Zimbabwe. There is a need for capacity building to incorporate comprehensive TIT testing and optimize cancer care in Zimbabwe.
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