Prevalence and Predictive Value of the Thrombin-Antithrombin Complex Levels in Patients with Abdominal Aortic Aneurysm and Peripheral Arterial Disease Undergoing Endovascular Interventions

Abstract

Introduction: The level of activation of fibrynolitic system among patients with vascular disorders influences the course of their diseases as well as the results of operations and postoperative follow-up. While the activation ot thrombin cannot be measured directly, because it connects with antithrombin forming the complex, Therefore, the assesment of thrombin - antithrombin (TAT) complex levels in the blood serum of that patients seems to be the reasonable method to estimate their susceptibility to postoperative complications. Methods: 60 patients were included in the study: 20 with AAA and 40 with PAD. Among patients with PAD: 20 were treated with PTA for the first time and 20 were treated with PTA due to the restenosis after PTA pefrformed beforehand. 20 healthy volunteers were the control group. All the patients (and volunteers) had the sample of the blood collected in admission to the hospital and the level of the TAT coplex were measured. Results: The mean levels of the TAT complexes in the blood serum among patients with AAA were 10,6g/l. Therefore they were elevated more than twice above the norm (4,1g/l). Patients with PAD admitted for the first-time PTA had the mean level of TAT complexes sligtly elevated (mean4,8g/l), but patients with PAD admitted to treat the postoperative complications (restenosis after PTA) had the levels of TAT complexes even higher than patients with AAA (mean 11,8g/l). The levels of the TAT complexes among healthy volunteers did't exceed the norm (max.4g/l). Conclusion: The measurment of the levels of the TAT complexes in the blood serum among the patients with vascular disorders seem to be the good method of assessment of the severity of their disease as well as their susceptibility to complications. The correlation between the thrombin - antithrombin complex levels and patients' susceptibility to complications after the endovascular interventions (which is the subject of our ongoing study) should reveal the predictive value of this method in the nearest future. Disclosure: Nothing to disclose