Abstract
Introduction: Dyslipidaemia is one of the major risk factors for cardiovascular disease (CVD) in diabetes mellitus. However, the magnitude and characteristic features of dyslipidaemia among Sri Lankans with newly diagnosed diabetes is not yet known.We aimed to study the prevalence and pattern of dyslipidaemia in a cohort of patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods: This study was carried out in 403 newly diagnosed T2DM patients attending a specialist diabetic clinic in Southern Sri Lanka. Dyslipidaemia was diagnosed if patients had one or more parameters of lipid profile outside the target values recommended by theAmerican DiabetesAssociation (ADA). Results: Diabetic dyslipidaemia was observed in 90% of patients with females having higher prevalence (94.7%) than males (87.0%, P=0.04). The most prevalent type of dyslipidaemia was isolated elevation of low density lipoprotein (LDL) cholesterol (84.3%) Raised triglyceride (TG) and low high density lipoprotein (HDL) were comparatively less common and observed in less than 20% subjects. Factors such as obesity, waist circumference, age and degree of hyperglycaemia at presentation had no significant effect on the pattern and prevalence of dyslipidaemia. Conclusions: This study revealed a higher prevalence and a different pattern of dyslipidaemia among newly diagnosed patients with T2DM. Finding of raised LDL with relatively low TG observed in this study was different to the pattern of diabetic Dyslipidaemia described in Caucasians.
Highlights
Dyslipidaemia is one of the major risk factors for cardiovascular disease (CVD) in diabetes mellitus
Following patients were excluded from the study; patients currently on treatment for dyslipidaemia, patients who have been treated for diabetes in past, those who were unwell due to hyperglycaemia or intercurrent illness, clinically apparent hypothyroidism, nephrotic syndrome and chronic kidney disease, those with extreme body habitus (BMI40), and when type 1 diabetes or secondary causes for diabetes were more likely on clinical grounds than type 2 diabetes mellitus (T2DM)
The prevalence of dyslipidaemia is high among newly diagnosed patients with T2DM affecting over 90%
Summary
Dyslipidaemia is one of the major risk factors for cardiovascular disease (CVD) in diabetes mellitus. We aimed to study the prevalence and pattern of dyslipidaemia in a cohort of patients with newly diagnosed type 2 diabetes mellitus (T2DM). Patients with type 2 diabetes mellitus (T2DM) are at higher risk of developing coronary artery disease (CAD) and other vascular diseases such as ischemic stroke. ADA in 2016 update recommends moderate-intensity statin treatment for all patients with diabetes aged >40 years and high-dose statins for those with increased cardiovascular risk [e.g., LDL cholesterol >100 mg/dL (2.6 mmol/L)], high blood pressure, smoking, albuminuria, and family history of premature coronary artery disease) [5].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
