Abstract
In this retrospective cohort study based in Taiwan, we reported the current epidemiology of patients with multiple myeloma and analyzed the factors affecting mortality. We identified 7285 patients with newly diagnosed multiple myeloma (MM) between 1997 and 2013 in Taiwan. Privileges data from the National Health Institute Research Database was used, as it is made readily available to the public in electronic format for research purposes. From 1997 to 2013, the average incidence of MM per 100,000 people was 1.83. The mortality accounted for an average of 0.44 per 100,000 deaths. In all 7285 inpatients with MM, the proportion of male patients was greater than that of female (59.90% vs. 40.10%); the mean age was 68.71 years with the proportion of those >55 years of age was 85.11%; and the proportion of a catastrophic illness was 66.51%. The death risk of the inpatient dialysis group was 3.044 times that of patients without dialysis (P <0.001). Moreover, the risk of death to men in the hospital setting was 1.162 times that of women (P = 0.012), and in the group of patients aged >55 years, the risk of in-hospital death was 1.511 times more than that in those aged ≤55 years (P <0.001). The risk of hospital death due to catastrophic illness was 1.347 times that of a non-catastrophic illness (P <0.001). Male patients and those >55 years of age had the most common prevalence of MM in Taiwan. Hemodialysis treatment, male sex, old age, and catastrophic illness were independent predictors of hospital mortality in patients with MM.
Highlights
Multiple myeloma (MM) is a cancer of plasma cells, white blood cells that are naturally responsible for producing antibodies [1,2]
The proportion of a catastrophic illness, a severe illness requiring prolonged hospitalization or recovery [9], was 66.51%; the Charlson comorbidity index (CCI) with disease index score was 0.65 points, but there are not different form survive group and mortality group (P = 0.495); and there was a higher proportion of autumnal hospitalization (28.00%)
To the best of our knowledge, this is the first large-population based study regarding the epidemiology of MM in Chinese populations in recent years
Summary
Multiple myeloma (MM) is a cancer of plasma cells, white blood cells that are naturally responsible for producing antibodies [1,2]. MM resulted in about 74,000 deaths in 2010, up from 49,000 in 1990 [3]. These numbers are established on assumptions made using data from 2011, which estimated the prevalence at 83,367 people, the incidence at 6.1 per 100,000 people per year, and the mortality at 3.4 per 100,000 people per year [4]. Asians have the lowest reported incidence of MM, with men affected slightly more than women do. The reported age-adjusted incidence of MM per 100,000 people around the world is 0.5 in Hawaiian Japanese men [5,6]. Recent reports have suggested that the incidence of MM is increasing in some Asian countries [7,8]
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