Abstract
BackgroundLoiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the second or third most common reason for medical consultation after malaria, and a recent study has reported an excess mortality associated with the infection. However, the clinical impact of this filarial disease is yet to be elucidated, and it is still considered a benign disease eliciting very little attention. As a consequence of post-treatment severe adverse events occurring in individuals harboring very high Loa microfilarial loads, ivermectin is not recommended in onchocerciasis hypo-endemic areas that are co-endemic for loiasis. Without treatment, it is likely that the transmission of the disease and the morbidity associated with the infection will increase over time. This study aimed at investigating the long-term trends in prevalence and intensity of Loa loa infection in an area where no mass anti-filarial treatment has ever been distributed.MethodsA cross-sectional survey was conducted in three communities of the Mbalmayo health district (Central Cameroon). All volunteers, males and females aged five years and above, underwent daytime calibrated thick blood smears (CTBS) to search for L. loa microfilariae (mf). A structured questionnaire was administered to assess the history of both loiasis related clinical signs and migration of enrollees.ResultsThe prevalence of loiasis was 27.3% (95% CI: 22.3–32.9) in the three surveyed communities, with a mean mf density of 1922.7 (sd: 6623.2) mf/mL. Loa loa infection rate was higher amongst females than in males (p = 0.0001) and was positively associated with age of (OR = 1.018; p = 0.007). The intensity of infection was higher among males than in females (p < 0.0001), and displayed a convex in form trends with age groups. The follow up over 23 years revealed that both the rate and intensity of infection were similar to baseline.ConclusionsThe prevalence and intensity of Loa loa infection 23 years on is stable over time, indicating that this filarial disease might be noncumulative as regarded till now.
Highlights
Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops
Prevalence Among the 271 individuals examined, 74 (27.3%; 95% confidence interval (CI): 22.3–32.9) were harboring L. loa microfilariae in their blood
The prevalence of loiasis was similar among communities visited (Chi-square: 1.604; p = 0.448), a high heterogeneity was observed in Loa distribution between genders and age groups (Table 1)
Summary
Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the second or third most common reason for medical consultation after malaria, and a recent study has reported an excess mortality associated with the infection. The clinical impact of this filarial disease is yet to be elucidated, and it is still considered a benign disease eliciting very little attention. Better known as the African eye worm, is a parasitic disease caused by the filarial nematode Loa loa and transmitted to humans by tabanids belonging to the genus Chrysops. Loiasis is still considered a benign disease eliciting very little attention, a recent survey has reported an excess mortality associated with the infection [7]
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