Abstract
IntroductionMalnutrition is a common sequela of chronic pancreatitis (CP). Alterations in body composition and the assessment of sarcopenia have gained the interest of clinicians in recent years. There is a scarcity of data currently available concerning sarcopenia in patients with CP. This review aims to investigate the prevalence and impact of sarcopenia in CP.MethodsEmbase and Medline databases were used to identify all studies that evaluated sarcopenia and outcomes in patients with chronic pancreatitis. Due to paucity of data, conference abstracts were included. PRISMA guidelines for systematic reviews were followed.ResultsSix studies, with a total of 450 individuals were reviewed. Three full-text studies and three conference abstracts met the predetermined eligibility criteria. The prevalence of sarcopenia in CP from all studies ranged from 17–62%. Pancreatic exocrine insufficiency was associated as an independent and significant risk factor for sarcopenia. Sarcopenia was found to be associated with a reduced quality of life, increased hospitalisation, and reduced survival. It was associated with significantly lower islet yield following total pancreatectomy with islet auto transplantation in CP.ConclusionThe review of these existing studies amalgamates the limited data on sarcopenia and its impact on CP. It has shown that sarcopenia is exceedingly prevalent and an important risk factor in CP patients. The data presented emphasises that sarcopenia has a significant prognostic value and should be included in future prospective analyses in the outcomes of CP.
Highlights
Introduction Malnutrition is a common sequela of chronic pancreatitis (CP)
The review of these existing studies amalgamates the limited data on sarcopenia and its impact on CP
It has shown that sarcopenia is exceedingly prevalent and an important risk factor in CP patients
Summary
Alterations in body composition and the assessment of sarcopenia have gained the interest of clinicians in recent years. This review aims to investigate the prevalence and impact of sarcopenia in CP. Malnutrition is a common sequela of chronic pancreatitis (CP). Variations in body composition and the assessment of sarcopenia have gained the interest of clinicians in. Sarcopenia and serum albumin levels are reported to be intimately linked with pancreatic exocrine insufficiency (PEI) in patients with CP [11]. Current available data on the impact of sarcopenia on the prevalence and outcomes in CP are scarce with only a handful of studies reporting on sarcopenia in pancreatic ductal adenocarcinoma (PDAC).
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