Abstract

BackgroundHuman papillomavirus (HPV) DNA testing is an important method in cervical cancer screening. However, the studies on prevalence and genotype distribution of HPV among women in northeastern Guangdong Province of China are very limited.MethodsA total of 28,730 women attending the Department of Gynecology of Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University between January 1st, 2013 and June 1st, 2015 were enrolled in this study. HPV type-specific distribution was tested using flow-through hybridization and gene chip.ResultsThe overall prevalence of HPV infection was 19.81%, among which 79.09% were infected with high-risk HPV subtypes in the subjects. The 5 most predominant genotypes were HPV16, 52, 58, 18 and 81. Most HPV infections were observed in women aged 41–50 and women aged 30–59 accounted for a proportion of over 80%.ConclusionsOur findings suggested a high burden of HPV infection among women in northeastern Guangdong Province of China. We identified the top 5 HPV genotypes as well as the age-specific distribution of HPV infections in this area.

Highlights

  • Human papillomavirus (HPV) DNA testing is an important method in cervical cancer screening

  • * Correspondence: zhaopingsen01@163.com; zhaopingsen@hotmail.com †Equal contributors 1Clinical Core Laboratory, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, People’s Republic of China 2Center for Precision Medicine, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, People’s Republic of China Full list of author information is available at the end of the article and neck cancers (HNCs), among which are up to 60% of the oropharyngeal carcinoma (OPC) [2]

  • We detected and genotyped Human papilloma virus (HPV) infection among women attending Department of Gynecology of Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University during 2013–2015

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Summary

Introduction

Human papillomavirus (HPV) DNA testing is an important method in cervical cancer screening. The studies on prevalence and genotype distribution of HPV among women in northeastern Guangdong Province of China are very limited. Human papilloma virus (HPV) is a kind of doublestranded DNA virus without enveloped icosahedral capsids. This virus infects epithelium of cutaneous or mucosal tissues [1]. HPV infection is known as the major causes of cervical cancers, some vaginal, vulvar, and penile cancers. As the third most common type of cancers in women, cervical cancer accounts for 9% of the total new diagnosed cancer cases and 8% of the total cancer deaths among females respectively.

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