Abstract
Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (χ2=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).
Highlights
Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide (Jemal et al, 2011)
The sensitivity of visual inspection and Pap smear might depend on the experience and training of the health workers, human papillomavirus (HPV) DNA testing would be an alternative method for objectively screening HPV infection with high sensitivity and moderate specific (Zhao et al, 2010)
A series of studies have been conducted to assess the prevalence of HPV genotypes in China, such as Shanghai, Zhejiang and, Shenzhen, fewer are referred to Henan province (Xue et al, 2009; Ye et al, 2010; Wang et al, 2013)
Summary
Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide (Jemal et al, 2011). More than 80% of the women diagnosed with cervical cancer live in the developing countries, such as China and Indian, the cervical cancer has been an important public health concern (Li et al, 2013; Rai et al, 2014). Several methods, such as visual inspection using acetic acid or Lugol’s iodine, the conventional Pap smear and human papillomavirus (HPV) DNA testing, had been implemented for the screen of cervical cancer. A series of studies have been conducted to assess the prevalence of HPV genotypes in China, such as Shanghai, Zhejiang and, Shenzhen, fewer are referred to Henan province (Xue et al, 2009; Ye et al, 2010; Wang et al, 2013)
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