Abstract
Rotavirus infection is the major cause of acute gastroenteritis among children globally. Sub-Saharan Africa including Ethiopia is disproportionally affected by the disease. The aims of this review were to determine the pooled prevalence of rotavirus infection among children under-five and to identify the dominant rotavirus genotypes in Ethiopia. Twelve studies were included to estimate the pooled prevalence of rotavirus acute gastroenteritis and five studies were used to determine predominantly circulating genotypes of rotavirus. The pooled prevalence of rotavirus infection was 23% (95% CI = 22%–24%). G3 (27.1%) and P[8] (49%) were the dominant G and P types, respectively. The G8 G-type uncommon in humans but highly prevalent in cattle was also reported accounting for 1% of all cases. The major G/P combinations were G12P[8] (15.4%), G3P[6] (14.2%), G1P[8] (13.6%) and G3P[8] (12.9%) collectively accounting for 56.1% of rotavirus strains. Similar to other parts of the world, the dominance of G1, G3, P[6] and P[8] genotypes was noted in Ethiopia. The increased prevalence of G12P[8] strains observed in Ethiopia was similar to observations in other geographic regions in the post-vaccine introduction period. Thus, further studies are required on the vaccine effectiveness, genotype distribution and inter-species transmission potential of rotaviruses in Ethiopia.
Highlights
Diarrhea is the second most frequent cause of death among young children globally following respiratory tract infections [1]
We have looked at the prevalence of rotavirus infection before and after the introduction of rotavirus in Ethiopia
This can potentially lead to mismanagement of rotavirus acute gastroenteritis with antibiotics in the absence of appropriate diagnostic tools for acute viral gastroenteritis in health facilities of Ethiopia; which in turn contributes to the problem of antimicrobial resistance in the country
Summary
Diarrhea is the second most frequent cause of death among young children globally following respiratory tract infections [1]. Diarrhea is responsible for 25%–30% of deaths [2]. Rotavirus remains the leading cause of severe gastroenteritis worldwide [3]. According to the World Health Organization report in 2016, there were 215,000 deaths due to rotavirus infection in children less than five years old in 2013 globally. In Ethiopia there were 6817 deaths due to rotavirus infection in the same year [4]. Number (%) Overall Number G1P[4] G1P[6] G1P[8] G2P[4] G2P[6] G3P[6] G8P[6] G8P[8] G9P[4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
