Prevalence and drug resistance patterns of bacteria isolated from wound and bloodstream nosocomial infections in Hamadan, West of Iran

Abstract

Nosocomial infections are important causes of morbidity and mortality. There are inconsistent results among the antimicrobial resistance patterns of nosocomial infections. This study aimed to investigate the antimicrobial resistance patterns of bacteria isolated from the bloodstream and wound nosocomial infections among the inpatients in Hamadan, 2019–2020. In this study, the concurrent surveillance for nosocomial bloodstream and wound infections at three hospitals over 2 years detected and identified the nosocomial pathogens; then, they were surveyed antibiotic resistance. For this reason, we used API and disk diffusion methods. 2583 patients were enrolled in which 311 positive blood samples, 148 wound samples were isolated. In wound infections, the highest resistance rate of isolated bacteria to a wide range from the antibiotics was related to A. baumannii, P. aeruginosa, and E. coli, respectively. In blood infections, the highest resistance rate of isolated bacteria was related to A. baumannii, S. saprophyticus, and P. aeruginosa, respectively. These data could be helpful for the clinicians to decide better about target empirical therapy for the hospital-acquired cases of bacteremia and wound infections; however, it was concerned the isolates should properly monitor for a choice of antibiotics to be used as prophylaxis, and empiric treatment.