Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China

Xiangpeng Wang,Guanyu Wang,Ruili Sun,Yuan Song,Lijun Zhao,Mingyong Wang,Xiaofei Wei

doi:10.1186/s12985-021-01732-8

Xiangpeng Wang, Guanyu Wang + Show 5 more

Open Access

https://doi.org/10.1186/s12985-021-01732-8

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Abstract

BackgroundHuman papillomavirus (HPV) infection can cause cervical and other cancers, including vulva, vagina, penis, anus, or oropharynx. However, in China's northern Henan Province, data on the prevalence and genotype distribution of HPV among women attending gynecology clinics is limited. This study aimed to investigate the current prevalence and genotype distribution of HPV among women attending gynecology clinics in northern Henan Province.MethodsThis study included 15,616 women aged 16–81 years old who visited the Xinxiang central hospital's gynecology department between January 2018 and December 2019. HPV DNA was detected by a conventional PCR method followed by HPV type-specific hybridization, which was designed to detect 17 high-risk HPV (HR-HPV) genotypes and 20 low-risk HPV (LR-HPV) genotypes. HPV prevalence and corresponding 95% confidence intervals (95% CI) were calculated using SPSS 18.0.ResultsThe overall HPV prevalence was 19.7% among women in northern Henan Province. Single, double, and multiple HPV infections accounted for 13.7%, 4.3%, and 1.8% of the total cases. Most infections were caused by HR-HPV (71.8%), and single genotype HPV infection (13.7%) was the most common pattern. The most common HR-HPV genotype was HPV16 (4.3%), followed by HPV52 (3.5%) and HPV58 (2.0%). The most common LR-HPV genotype was HPV6 (1.4%), followed by HPV61 (1.1%) and HPV81 (1.1%).ConclusionsHPV infection is high among women attending gynecology clinics in northern Henan Province. The highest prevalence was found in women less than 20 years old. In northern Henan Province, the 9-valent HPV vaccine is strongly recommended for regular immunization.

Highlights

Cervical cancer, ranked after breast cancer, colorectal cancer, and lung cancer, is the fourth most common cancer among women worldwide, with approximately 530,000 new cases and 275,000 deaths every year [1,2,3]
Overall and age‐specific Human papillomavirus (HPV) prevalence From January 2018 to December 2019, 15,616 cervical specimens collected for HPV DNA detection were used for statistical analysis
There were 3081 specimens positive for any HPV DNA, and the overall prevalence of HPV was 19.7%

Summary

Introduction

Cervical cancer, ranked after breast cancer, colorectal cancer, and lung cancer, is the fourth most common cancer among women worldwide, with approximately 530,000 new cases and 275,000 deaths every year [1,2,3]. HPV infection can cause cervical cancer and other cancers, including the vulva, vagina, penis, anus, or oropharynx. Persistent infection with HR-HPV is the major cause of cervical cancer. Since persistent infection with HR-HPV is a necessary cause for cervical cancer development, DNA detection and genotyping of HPV can be an essential method for controlling and preventing HPVrelated diseases in China. Human papillomavirus (HPV) infection can cause cervical and other cancers, including vulva, vagina, penis, anus, or oropharynx. In China’s northern Henan Province, data on the prevalence and genotype distribution of HPV among women attending gynecology clinics is limited.

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