Abstract
China is still among the 30 high-burden tuberculosis (TB) countries in the world and TB remains a public health concern. TB can be a cause of mental illness, with prolonged treatment and several anti-TB drugs leading to extreme mental health problems such as depression and anxiety in TB patients. To investigate the prevalence of anxiety and depressive symptoms among TB patients, and to explore whether drug resistance is a covariate for depressive and anxiety symptoms, a total of 167 pulmonary tuberculosis patients were enrolled in this study, which was conducted from January 1 to September 30, 2020. Data were collected, using a structured questionnaire with a demographic component, the Hospital Anxiety and Depression Scale (HADS), General Health Questionnaire 20 (GHQ-20), the Tuberculosis-related Stigma Scale (TSS) and the Social Support Rating Scale (SSRS). Association between demographics, disease/treatment characteristics, stigma, social support, and anxiety/depression symptoms were investigated either based on Pearson's correlation coefficient or group comparisons based on independent t-test (or Mann-Whitney U-test) Multiple linear stepwise regression analysis was used for determining the predictors of anxiety and depression. The results showed that multi-drug resistance pulmonary tuberculosis patients were associated with anxiety challenges. Multiple linear regression analysis indicated that self-esteem accounted for 33.5 and 38% of the variation in anxiety and depression, respectively. This shows that among tuberculosis patients, self-esteem is the factor that could most explains the depression and anxiety symptoms of patients, suggesting that we may could through improving the environment, society, and family respect and tolerance of tuberculosis patients, thereby improving the mental health of tuberculosis patients.
Highlights
Tuberculosis (TB) is a chronic infectious disease caused by mycobacterium tuberculosis
This study aimed to investigate the prevalence and correlates of anxiety and depressive symptoms among pulmonary TB patients, and explore whether TB-drug resistance was associated with greater anxiety and depressive symptoms
Inclusion criteria: [1] TB patients meeting the diagnostic criteria: drug-sensitive TB was based on drug susceptibility testing which showed that mycobacterium tuberculosis were susceptible to all of the antiTB drugs; MDR-TB was based on drug susceptibility testing which showed that mycobacterium tuberculosis were resistant to at least isoniazid and rifampicin simultaneously
Summary
Tuberculosis (TB) is a chronic infectious disease caused by mycobacterium tuberculosis. It is one of the leading causes of morbidity and mortality worldwide [1]. Anxiety and depression are the most common mental disorders in the general population. Patients with TB may suffer from mental disorders as a result of long-term treatment, anti-TB drug side effects and TB relapses [4]. Studies on the prevalence of anxiety and depression in TB patients in different countries or regions showed that the prevalence of anxiety and depression in TB patients is about 40.67–72.88% and 9.93–61%, respectively [3, 5,6,7,8]. A study in China showed that the prevalence of anxiety and depression in TB patients is about 18.37 and 18.13%, respectively [4]
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