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Abstract
BackgroundThe aim of this study was to make an in-depth analysis of the prevalence and co-occurrence in pre-school children of possible asthma and atopic manifestations.MethodsIn Sweden 74%-84% of preschool children, depending on age, attend municipality organised day-care centres. Parents of 5,886 children 1–6 years of age, sampled from day-care centres in 62 municipalities all over Sweden, responded to a postal questionnaire regarding symptoms indicating prevalent possible asthma, allergic rhinitis, eczema, and food, furred pet and pollen allergy and other data in their children. Possible asthma was defined as any of the four criteria wheezing four times or more during the last year, physician diagnosis and current wheezing, ever had asthma and current wheezing, and current use of inhalation steroids, all based on questionnaire responses.ResultsThe overall prevalence of possible asthma was 8.9%, of eczema 21.7%, of rhinitis 8.1%, and of food allergy 6.6%. There was a highly significant co-occurrence between possible asthma and all atopic manifestations, 35.7% having any of the manifestations. Presence of pet allergy was the manifestation showing the closest co-occurrence with presence of possible asthma, presence of pollen allergy with presence of rhinitis, and presence of food allergy with presence of eczema. Assessed from plots of age-specific prevalence of possible asthma, rhinitis, eczema and food allergy, the prevalence of all manifestations increased from one to three years of age and then decreased, except for rhinitis where the prevalence increased until six years of age, indicating no specific ordered sequence.ConclusionsParentally reported possible asthma, eczema and food allergy had a curvilinear prevalence course across age with a maximum at age 3, while rhinitis prevalence increased consistently with age. Co-occurrence between possible asthma and atopic manifestations was common, and some combinations were more common than others, but there was no evidence of a specific ordered onset sequence.
Highlights
The aim of this study was to make an in-depth analysis of the prevalence and co-occurrence in preschool children of possible asthma and atopic manifestations
The age distribution was similar in the avoidance day-care centres’ (AADCs) children
The prevalence of possible asthma manifestations was stable or decreased by age, while the prevalence of rhinitis manifestations was stable or increased, and the prevalence of eczema manifestations was generally stable, except that ointment treatment became less prevalent by age
Summary
The aim of this study was to make an in-depth analysis of the prevalence and co-occurrence in preschool children of possible asthma and atopic manifestations. According to the International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence of asthma and rhino-conjunctivitis among 6- to 7-year-old children in Sweden in 2002 was in the middle of the international range, whereas the prevalence of eczema was the highest of all countries participating [1,3]. There are few published studies on age-specific prevalence of asthma, allergic rhinitis called rhinitis, eczema, and food allergy [7,8]. It is well known that that there is co-occurrence between asthma and various atopic manifestations. The information on the extent of co-occurrence is still fragmentary [9,10,11]
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