Prevalence and Clinical Correlates of Right Ventricular Dysfunction in Patients with Hypertrophic Cardiomyopathy

Abstract

Purpose Previous studies have shown that hypertrophic cardiomyopathy (HCM) can also affect the right ventricle (RV), but there are not univoque data about it. The aim of this study is to describe RV dysfunction in patients with HCM using the myocardial performance index (MPI), tricuspid annular plane systolic excursion (TAPSE) and RV fractional area change (RVFAC) and their association with clinical outcome. Methods and Materials Consecutive patients with HCM followed at Stanford Hospital from 1999 to 2012 were included in the study. A total of 324 patients with HCM were included in the study. A group of 99 age and sex matched healthy volunteers were used as controls. Multivariable regression analysis was used to determine independent correlates of RV function. Results Compared to matched controls, patients with HCM had higher RVMPI (0.51±0.18 vs. 0.25±0.06, p 0.4 (HR 3.13 per 0.3, CI 95% 1.63 to 6.0, p Conclusions RV dysfunction based on RVMPI is common in patients with HCM and is more frequently observed among patients with LV dysfunction and pulmonary hypertension. RV dysfunction based on RVMPI was associated with a history of syncope, defibrillator discharge or lower maximal VO2.